东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Shigeru Tsunoda's research lab specializes in translational oncology with a focus on esophageal squamous cell carcinoma (ESCC). The lab investigates molecular mechanisms underlying tumor progression, including the roles of ABCG2-positive cells and nerve growth factor (NGF) signaling in cancer aggressiveness and metastasis. Their work integrates clinical pathology with molecular biology to identify novel prognostic biomarkers and therapeutic targets. The lab also evaluates surgical outcomes and postoperative imaging in gastrointestinal malignancies, emphasizing early detection and intervention.
Professor Jun Shimokawa's research lab specializes in the development of innovative synthetic methodologies for complex natural products, with a strong emphasis on total synthesis and strategic bond-forming transformations. The lab focuses on designing efficient, stereoselective routes to bioactive natural products—particularly those with challenging architectures such as spirocyclic systems, guanidines, and azetidines—using novel reactivity patterns like divinylcyclopropane rearrangements and transition-metal-catalyzed silylation. A central theme is the creation of versatile, late-stage intermediates inspired by biosynthetic pathways to enable divergent synthesis of natural product families. The lab also explores the unique reactivity of silanols in transition metal catalysis, positioning them as key tools in modern organic synthesis.
Professor Hirokazu Tatano's research lab specializes in disaster risk assessment and spatial economic resilience, focusing on the interplay between urban vulnerability, climate-induced hazards, and socioeconomic inequality. The lab investigates flood risk in urban environments using multivariate hydrological modeling and copula-based methods to integrate multiple flood sources, particularly in small basins. It also examines the long-term economic impacts of large-scale disasters through endogenous growth models, emphasizing spatially heterogeneous capital destruction and recovery dynamics. A central theme is the integration of everyday livelihood risks with disaster preparedness in low-income urban settlements, especially in megacities like Mumbai.
Professor Hiroki Shiomi's research lab specializes in interventional cardiology and structural heart disease, with a primary focus on optimizing reperfusion strategies and revascularization outcomes in acute myocardial infarction and complex coronary artery disease. The lab investigates time-sensitive interventions such as door-to-balloon and onset-to-balloon times in ST-elevation myocardial infarction (STEMI), emphasizing the clinical impact of reducing delays in treatment. Additionally, the lab conducts comparative effectiveness research on coronary revascularization strategies, particularly evaluating the long-term benefits of coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI) in patients with left main coronary artery disease (ULMCAD), especially those with high anatomical complexity. Their work aims to guide evidence-based decision-making in interventional cardiology to improve patient survival and quality of life.
Professor Dongsheng Wu's research lab specializes in advanced welding and additive manufacturing processes, with a focus on the multi-physics modeling of arc welding, keyhole dynamics, and molten pool behavior. The lab investigates the complex interactions between thermal, fluid, and electromagnetic forces in processes such as keyhole plasma arc welding (KPAW), wire arc additive manufacturing (WAAM), and tandem TIG welding, particularly for high-performance alloys like γ-TiAl and aluminum alloys. Experimental validation using high-speed imaging and advanced diagnostics is integrated with numerical simulations to optimize process stability, element distribution, and energy efficiency. The lab's work aims to enhance the quality, reliability, and efficiency of modern joining and additive manufacturing technologies.
Professor Ramy Gadallah's research lab specializes in the mechanical behavior and structural integrity of welded joints, with a strong focus on fracture mechanics, residual stress analysis, and fatigue life prediction in high-strength and structural steels. The lab employs advanced numerical methods such as the finite element method (FEM), interaction integral, and domain integral techniques to evaluate stress intensity factors (SIFs) and assess crack driving forces under complex loading and welding conditions. Key research directions include the influence of shielding gas composition on weld quality in flux-cored arc welding, the role of welding sequences in residual stress development, and the effects of tensile overloads on fatigue performance. The lab also contributes to experimental validation using advanced measurement techniques like the contour method for residual stress reconstruction.
Professor Tetsuya Kodama's research lab specializes in biomedical engineering and sustainable energy technologies, with a focus on therapeutic angiogenesis, targeted drug delivery using ultrasound and microbubbles, and solar-driven thermochemical processes for hydrogen and syngas production. The lab develops innovative animal models for lymph node metastasis and applies advanced imaging techniques to study cancer progression and drug delivery. It also pioneers solar reactor systems using fluidized bed technology for clean fuel production.
Professor Hisashi Nakamura's research lab specializes in experimental and numerical studies of chemical kinetics, particularly focusing on ammonia oxidation at intermediate temperatures and in fuel-rich conditions. The lab employs advanced reactor systems such as micro flow reactors with precise temperature control to investigate fundamental reaction mechanisms. Additionally, the lab develops high-precision control systems, including innovative phase-locked loop-based servo controllers, for high-performance motion control in industrial applications like precision gear grinding. The integration of chemical kinetics and advanced mechatronics defines the lab’s interdisciplinary approach.
Professor Jun Inoue's research lab focuses on viral hepatitis, particularly hepatitis B and E viruses, with an emphasis on understanding the molecular mechanisms of viral replication, pathogenesis, and host-virus interactions. The lab investigates viral genetics, host cellular pathways such as the multivesicular body and autophagy systems involved in viral assembly and secretion, and the development of antiviral strategies targeting viral entry and replication. They also conduct epidemiological studies to assess the prevalence and clinical impact of hepatitis B and delta virus infections in specific populations.
Professor Masaki Okumura's research lab focuses on the molecular mechanisms underlying protein folding, disulfide bond formation, and the function of key enzymes such as protein disulfide isomerase (PDI) and plasma membrane H⁺-ATPase in plants and animals. The lab investigates how redox environments, post-translational modifications like phosphorylation, and protein-protein interactions regulate protein homeostasis and cellular function. Using biochemical, biophysical, and structural approaches—including NMR, X-ray crystallography, and protein engineering—the lab aims to decipher the dynamic regulation of folding catalysts and ion pumps in health and disease.
Professor Kyoko Chiba's research lab focuses on the molecular mechanisms underlying axonal transport in neurons, with a central emphasis on kinesin superfamily proteins (KIFs) such as KIF1A, KIF5A, and kinesin-1. The lab investigates how mutations in these motors lead to neurodegenerative diseases like hereditary spastic paraplegia (SPG), amyotrophic lateral sclerosis (ALS), and Alzheimer’s disease, using biochemical, biophysical, and live-cell imaging approaches. A key research direction involves understanding the regulation of motor activity through autoinhibition, cargo adaptor interactions, and pathological protein aggregation. The lab also develops innovative imaging tools, such as KYMOMAKER, to enable high-throughput and accurate analysis of intracellular transport dynamics.
Professor Akihiko Hirata's research lab specializes in the atomic-scale characterization of amorphous and metallic glass materials, with a focus on understanding local atomic structures such as icosahedral order and geometric frustration. The lab employs advanced electron microscopy techniques—particularly angstrom-beam electron diffraction—combined with synchrotron X-ray scattering and computer simulations to probe the disordered structures of functional amorphous materials like silicon monoxide. In parallel, the lab explores photonic wireless communication systems using millimeter-wave technologies, emphasizing high-power, photonic-based mmWave signal generation and transmission. Their work bridges fundamental materials science with applied photonics, aiming to resolve long-standing structural mysteries in non-crystalline materials and develop next-generation communication technologies.
Professor Xiao Xu's research lab specializes in functional materials, with a primary focus on shape memory alloys, Heusler phases, and caloric materials for advanced applications. The lab investigates martensitic transformations, magnetic and mechanical properties, and phase transitions under thermal, magnetic, and mechanical stimuli, aiming to develop materials with unique functionalities such as cooling-induced shape memory effect and superelasticity. Key research directions include designing biomaterials with low Young's modulus and high wear resistance, as well as exploring shock-compression behaviors and solid-state refrigeration using elastocaloric effects in shape memory alloys. The lab integrates experimental techniques such as in situ XRD, TEM, and high-field magnetometry to uncover fundamental mechanisms and enable next-generation smart materials.
Professor Hisanori Fukunaga's research lab specializes in radiobiology and reproductive health, focusing on the effects of ionizing radiation—particularly low-dose and targeted radiation—on spermatogenesis and male fertility. The lab employs advanced models such as ex vivo testis organ culture and microbeam radiotherapy to investigate radiation-induced genotoxicity, mitochondrial dysfunction, and transgenerational effects. A key research direction involves understanding the developmental origins of health and disease (DOHaD) in the context of radiation exposure, with translational applications in oncofertility and radiation protection. The lab also explores tissue-sparing mechanisms in microbeam radiotherapy, aiming to preserve germ cell function while minimizing damage.
Professor Pan Liu's research lab specializes in the design and synthesis of advanced multi-component alloys and nanostructured materials for energy conversion and storage applications. The lab focuses on developing novel materials with exceptional thermal stability, electrochemical durability, and catalytic performance, particularly for fuel cells and electrolyzers. A key innovation is the application of dealloying strategies to engineer complex alloy systems with tailored surface and electronic structures. The research bridges materials synthesis, electrochemistry, and catalysis to enable sustainable energy technologies.
Professor Carlos Mendez's research lab specializes in regional economic development, with a focus on spatial inequality, convergence dynamics, and human capital constraints across regions and countries. The lab investigates regional disparities in productivity, income, and human development using advanced econometric methods such as dynamic factor models, distribution dynamics, and machine learning-based clustering. Research spans diverse contexts including Indonesia, Bolivia, and global cross-country comparisons, emphasizing institutional factors, spatial dependence, and policy implications for inclusive growth.
Professor Mineto Uchiyama's research lab specializes in the development of advanced polymerization methodologies, particularly focusing on metal-free, controlled cationic and reversible addition-fragmentation chain-transfer (RAFT) polymerizations. The lab pioneers innovative strategies for precise molecular weight control, narrow dispersity, and stereoregularity in the synthesis of functional polymers from electron-rich monomers such as vinyl ethers and alkoxy-substituted styrenes. A key innovation involves the use of triflic acid-mediated reversible chain-transfer agents—such as thiocarbonylthio compounds, thioethers, and phosphonates—to achieve 'living' polymerization behavior without transition metals. The lab also explores stimuli-responsive and degradable polymer architectures, including those with in-chain cleavable thioacetal bonds for controlled degradation.
Professor Ryo Kitaura's research lab specializes in the design and synthesis of functional metal-organic frameworks and coordination polymers with tailored porosity, dynamic structural responses, and confined nanospace environments. The lab focuses on creating stimuli-responsive materials that undergo reversible crystal-to-crystal transformations, enabling applications in gas storage, separation, and sensing. A key direction involves the precise control of metal centers and pore environments to host and stabilize small molecules such as O₂, H₂O, and MeOH, as well as to template low-dimensional nanomaterials like metal nanowires. The group employs advanced in situ characterization techniques, including synchrotron X-ray diffraction and Rietveld refinement, to probe structural dynamics at the atomic level.
Professor Atsushi Noro's research lab specializes in the design and synthesis of advanced functional materials based on supramolecular and block copolymer systems. The lab focuses on creating thermoreversible supramolecular polymer gels and ion gels through precise control of non-covalent interactions such as hydrogen bonding and metal–ligand coordination in ionic liquid media. Key research directions include microphase separation in block copolymers, the role of molecular architecture and dispersity in self-assembly, and the development of stimuli-responsive materials with tunable viscoelastic properties. The work bridges polymer chemistry, physical chemistry, and materials science to enable next-generation soft materials for sustainable and high-performance applications.
Professor Akane Tsushima's research lab specializes in paleoclimatology and environmental science, focusing on high-resolution ice core and tree-ring analyses to reconstruct past climate and environmental changes in high-altitude and high-latitude regions. The lab investigates atmospheric aerosols—particularly refractory black carbon—and stable isotopes in ice and tree rings to understand long-term climate variability, human impacts, and hydrological cycles in monsoonal and polar regions. Key research directions include developing advanced analytical techniques for ice core components and applying these to improve the accuracy of paleoclimatic reconstructions.
