东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Shotaro Yamashita's research lab specializes in welding metallurgy and process monitoring, with a primary focus on understanding and mitigating solidification and liquation cracking in high-performance alloys. The lab develops advanced in-situ temperature measurement techniques using multi-sensor and high-speed cameras combined with two-color thermometry to enable real-time, non-contact, two-dimensional temperature profiling during laser and arc welding. Their work emphasizes the quantitative evaluation of hot cracking susceptibility through innovative mechanical testing (e.g., Varestraint and U-type hot cracking tests) and numerical modeling of hot ductility behavior during solidification. The lab also investigates the fundamental role of solute elements—such as C, Ti, and Nb—in influencing cracking resistance in materials like Alloy 617 and carbon steel.
Professor Tomohiro Otani's research lab specializes in advanced photonic technologies and biomedical optics, with a strong focus on optical coherence tomography (OCT) for ophthalmic diagnostics and high-speed optical signal regeneration for next-generation optical communication networks. The lab investigates retinal structural integrity and its correlation with visual function in diseases like diabetic macular edema, while also developing all-optical 3R regenerators and wavelength-division multiplexing (WDM) systems for terabit-per-second optical transmission. Their work bridges medical imaging and optical engineering, emphasizing high-precision measurement techniques and robust photonic component design.
Professor Tsuyoshi Nagasawa's research lab specializes in advanced energy conversion and environmental materials, focusing on improving the efficiency and durability of clean energy technologies. Key research directions include developing innovative combustion strategies for internal combustion engines—such as thermal stratification via in-cylinder water injection—to enhance fuel efficiency under lean-burn conditions. The lab also investigates nanostructured catalysts, particularly Pt/CeO₂ systems synthesized via flame-assisted methods, for high-temperature applications in fuel cells and emission control. Additionally, the lab contributes to coastal environmental science by analyzing extreme natural disasters, such as the 2011 Tohoku tsunami, to understand structural and geomorphological impacts.
Professor Kiyoshi Takagi's research lab focuses on the pathophysiology of cerebral ischemia and the role of neurochemical and hormonal factors in breast cancer progression. The lab investigates neurovascular dynamics, including cerebral blood flow and excitotoxic neurotransmitter release (e.g., glutamate) during stroke using in vivo microdialysis and laser-Doppler flowmetry in rodent models. In parallel, the lab explores the molecular mechanisms of hormone-sensitive breast cancers, particularly the roles of androgens, aromatase inhibitors, and proteins such as NUCB2 and APP in tumor progression and recurrence. The research integrates preclinical models with clinical tissue analysis to identify novel therapeutic targets.
Professor A.L. Greer's research lab focuses on the fundamental science and engineering of metallic glasses and amorphous alloys, with a strong emphasis on microstructural design, nucleation control in solidification, and the mechanical behavior of non-crystalline materials. Key research directions include the mechanisms of inoculation in aluminum alloys, the rejuvenation of metallic glasses to enhance plasticity, and the role of microstructure in wear resistance and mechanical performance. The lab combines advanced characterization techniques—such as transmission electron microscopy and in-situ mechanical testing—with theoretical modeling to understand and tailor material properties at the atomic and microscale levels.
Professor Junichi Koike's research lab specializes in materials science with a focus on deformation mechanisms in lightweight metals, particularly magnesium alloys, and the development of advanced thin film materials for microelectronics. Key research directions include grain boundary sliding and twinning in Mg alloys under mechanical loading, the formation and stability of self-assembled diffusion barriers in Cu-Mn/SiO2 systems, and the fundamental understanding of radiation-induced defects and amorphization in crystalline materials. The lab combines advanced characterization techniques such as transmission electron microscopy, laser microscopy, and X-ray spectroscopy to investigate atomic-scale phenomena in functional materials.
Professor Yu Sakurai's research lab specializes in the development of advanced nanodelivery systems for targeted cancer therapy, with a focus on improving the delivery and efficacy of nucleic acid-based therapeutics such as siRNA. The lab investigates stimuli-responsive nanocarriers, including multifunctional envelope-type nanodevices (MENDs), to enhance tumor-specific delivery, intracellular trafficking, and gene silencing. Key research directions include overcoming drug resistance in renal cell carcinoma, modulating tumor vasculature through anti-angiogenic strategies, and optimizing nanoformulations for improved therapeutic outcomes. The lab also explores the interplay between tumor microenvironment modulation and drug delivery efficiency.
Professor Hidekazu Hiroaki's research lab specializes in structural biology and molecular pathology, with a focus on intrinsically disordered proteins (IDPs), protein-ligand interactions, and the structural and functional characterization of key regulatory proteins involved in disease pathways. The lab employs advanced NMR spectroscopy—both solution and in-cell NMR—to study dynamic protein conformations, protein self-assembly, and drug-target interactions, particularly in neurodegenerative diseases and cancer stem cells. They also develop innovative biochemical and biophysical tools, such as novel cloning systems and isotopic labeling strategies, to support high-resolution structural studies of biologically relevant peptides and proteins.
Professor Masamichi Hayashi's research lab specializes in molecular oncology and cancer biomarker discovery, with a focus on identifying epigenetic and genetic alterations underlying hepatocellular carcinoma (HCC) and pancreatic cancer. The lab investigates tumor suppressor genes such as AKAP12 and COL1A1, exploring their roles in cancer progression through promoter hypermethylation and gene expression regulation. A key research direction involves translating molecular findings into clinical applications, such as using gene methylation profiling of surgical margins to predict recurrence and guide surgical decision-making in head and neck cancers. The lab bridges basic molecular research with translational medicine to improve patient outcomes through precision oncology strategies.
Professor Keiko Kataoka's research lab focuses on the immunological and cellular mechanisms underlying retinal diseases, with a particular emphasis on the role of innate immunity, inflammasomes, and macrophage function in retinal pathologies such as retinal detachment and choroidal neovascularization. The lab investigates how microbial metabolites and fungal components like (1-->3)-beta-d-glucans modulate immune responses, especially in macrophages, and explores the interplay between the microbiota, host immunity, and tissue homeostasis. Using advanced imaging techniques such as OCTA, the lab examines vascular remodeling and maturation in pathological conditions, aiming to uncover therapeutic targets for vision-threatening diseases.
Professor Masafumi Inaba's research lab specializes in advanced semiconductor materials and nanostructured devices, with a focus on diamond-based electronics, silicon carbide power devices, and carbon nanotube-based sensors. The lab explores fundamental surface and interfacial phenomena in wide-bandgap semiconductors, including hydrogen-terminated diamond and SiC, to enable high-performance, high-frequency, and high-power electronic devices. Innovative fabrication techniques such as dielectrophoresis and atomic layer deposition are employed to engineer nano-heterostructures for sensing and power electronics applications. The lab also investigates novel 2D hole gas systems and vertical device architectures to push the limits of device performance and stability.
Professor Masafumi Moriyama's research lab focuses on the immunological mechanisms underlying autoimmune and fibrotic disorders, particularly IgG4-related disease (IgG4-RD) and Sjögren’s syndrome (SS). The lab investigates the roles of immune cells—especially M2 macrophages and T helper 2 (Th2) responses—in driving fibrosis and chronic inflammation in salivary and lacrimal glands. Key research directions include the signaling pathways involving TLR-7, IL-33, and NF-κB that regulate macrophage polarization and tissue remodeling. The lab also evaluates diagnostic biomarkers and biopsy utility for accurate differentiation of IgG4-DS from other glandular disorders.
Professor C. Hirose's research lab specializes in fluid dynamics and environmental fluid mechanics, focusing on urban wind environments and natural ventilation in buildings. The lab employs large-eddy simulations and experimental analysis to investigate how urban morphology and building geometry influence indoor and outdoor airflow, particularly in cross-ventilated spaces. A key research direction involves the behavior of gas bubbles in aquatic environments, especially methane bubbles and their interaction with methane hydrates, using both field observations and numerical modeling. The lab's work bridges environmental science, fluid dynamics, and urban planning to improve sustainable building design and understand natural gas seepage processes.
Professor Yuya Yoshida's research lab focuses on the pathophysiological roles of bioactive lipids and G protein-coupled receptors (GPCRs) in inflammatory and autoimmune diseases, with particular emphasis on sphingosine-1-phosphate (S1P) signaling in glioma and immune-mediated disorders. The lab investigates circadian clock regulation in cardiovascular and renal diseases, exploring how molecular circadian disruptions influence systemic inflammation and fibrosis. Additionally, the lab examines the therapeutic potential of S1P modulators like Fingolimod (FTY720) in autoimmune conditions such as experimental autoimmune encephalomyelitis and rheumatoid arthritis, especially in relation to treatment relapse and combination therapy. A translational aspect of the lab’s work includes evaluating diagnostic tools for orofacial pain, highlighting the need for improved clinical algorithms in oral medicine.
Professor Yoshihiro Sato's research lab specializes in transition-metal-catalyzed asymmetric synthesis, with a strong focus on the development of novel catalytic systems for stereoselective carbon-carbon bond formation. His group has made significant contributions to the fields of palladium- and nickel-catalyzed cyclizations, including [2+2+2] cocyclizations and three-component couplings, enabling efficient access to complex cyclic frameworks such as decalins, isoindolines, and arylnaphthalenes. The lab emphasizes the design of chiral ligands—particularly N-heterocyclic carbene (NHC) ligands—enabling high enantioselectivity and diastereoselectivity in these transformations. Their work has found key applications in the total synthesis of natural products, such as taiwanins C and E, highlighting the synthetic utility and precision of their methodologies.
Professor Atsuko Araki's research lab focuses on environmental health, particularly the impact of persistent organic pollutants such as phthalates and organophosphate esters (PFRs) on human health. The lab investigates prenatal and early-life exposure to these chemicals and their associations with respiratory diseases, allergies, and reproductive health outcomes. Using epidemiological and biomonitoring approaches, the lab examines the effects of chemical mixtures on children and infants, with an emphasis on indoor environmental exposures. Their work contributes critical insights into the health risks posed by ubiquitous household chemicals.
Professor Yusuke Matsuya's research lab specializes in radiobiology and radiation physics, focusing on the biological effects of ionizing radiation at the cellular and molecular levels. The lab integrates Monte Carlo track-structure simulations, mathematical modeling, and in vitro experiments to investigate DNA damage induction, sub-lethal damage repair, and cell survival under various radiation conditions. Key research directions include microdosimetric-kinetic modeling, non-targeted effects (bystander effects), and the radiobiological implications of protracted irradiation and boron neutron capture therapy (BNCT). The lab aims to improve the accuracy of radiation risk assessment and therapeutic outcome prediction in clinical radiotherapy.
Professor Toshiya Osanai's research lab specializes in regenerative medicine and neural tissue engineering, focusing on cell transplantation therapies for central nervous system disorders such as stroke and traumatic brain injury. The lab develops noninvasive imaging techniques—particularly near-infrared fluorescence imaging using quantum dots—to track transplanted bone marrow stromal cells (BMSCs) in living animals, enabling real-time monitoring of cell engraftment and migration. They also explore innovative delivery methods, such as intra-arterial transplantation and tissue-engineered hydrogels like TGP, to enhance cell survival and therapeutic efficacy. A key goal is to optimize cell-based therapies with improved safety, timing, and delivery strategies to maximize functional recovery in neurological patients.
Professor Atsushi Hosoi's research lab specializes in the mechanics and durability of advanced composite materials, with a primary focus on fatigue behavior, crack healing, and damage progression in fiber-reinforced plastics—particularly carbon fiber reinforced plastics (CFRP) and austenitic stainless steels. The lab investigates high-cycle and very-high-cycle fatigue mechanisms, ultrasonic and conventional fatigue testing methodologies, and innovative techniques such as electropulsing-assisted crack healing using surface-activated pre-coating (SAPC). A key research direction involves the quantitative evaluation of damage evolution, including transverse crack initiation and delamination growth, using advanced non-destructive evaluation techniques.
Professor Hisakazu Ohtani's research lab specializes in pharmaceutical and metabolic pharmacology, focusing on drug metabolism, drug-drug interactions, and the pharmacological effects of antibiotics and dietary factors. The lab investigates the mechanisms of cytochrome P450 enzyme inhibition—particularly CYP3A4 variants—and their implications in drug interactions, as well as the impact of cholesterol and fatty acids on lipid metabolism and lipoprotein dynamics. A key focus is on understanding the pharmacokinetic and pharmacodynamic profiles of macrolide antibiotics, especially their arrhythmogenic potential via QT interval prolongation.
