东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Takashi Nozawa's research spans cardiovascular physiology and microbial pathogenesis, with a focus on the biomechanics of cardiac function and the molecular mechanisms of bacterial immune evasion. His lab investigates ventricular efficiency and energy transfer in the heart using hemodynamic and volumetric measurements in animal models, while also exploring how pathogens like Group A Streptococcus manipulate host autophagy pathways through small GTPases such as Rab9A and Rab23. A key theme across his work is the interplay between host cellular machinery and microbial virulence factors, particularly in the context of horizontal gene transfer and immune modulation.
Professor Chie Hashimoto's research lab focuses on primate behavioral ecology and communication, with a particular emphasis on the interplay between environmental factors, human disturbance, and primate socioecology. The lab investigates how ecological gradients and anthropogenic impacts shape primate habitats and behavior, using advanced statistical methods such as principal component analysis to map vegetation and link it to animal distribution. A central theme is the role of operational sex ratio in shaping mating systems and social dynamics, especially in apes like bonobos and chimpanzees. The lab also explores the structure and function of animal communication, employing signal analysis to decode meaningful units in complex vocalizations.
Professor Yasuyuki Fujita's research lab focuses on the cellular and molecular mechanisms underlying epithelial homeostasis and early carcinogenesis, with a central emphasis on cell competition, tumor suppressor functions, and epithelial defense against cancer (EDAC). The lab investigates how normal and transformed epithelial cells interact at the interface, particularly the roles of proteins such as Lgl and mutant p53 in inducing selective elimination of pre-cancerous cells through apoptosis or necroptosis. Using Drosophila and mouse models, along with quantitative proteomics and live imaging, the lab explores how metabolic stress, inflammation, and soluble factors like ADAMDEC1 modulate these competitive interactions. A key theme is understanding how microenvironmental cues and systemic conditions—such as high-fat diet—compromise EDAC and promote tumor initiation.
Professor Yoshimitsu Shimomura's research lab specializes in molecular oncology and structural biology, focusing on the genetic and molecular mechanisms underlying hematological malignancies such as acute promyelocytic leukemia (APL) and lymphomas. The lab investigates novel fusion genes, including IRF2BP2-RARA in APL, and explores the structural and functional basis of enzymes involved in redox and metallocluster metabolism, such as quinone oxidoreductases and Fe–S cluster assembly systems. Their work integrates next-generation sequencing, structural biology, and clinical data to identify biomarkers and therapeutic targets in lymphoid malignancies.
Professor Tomoo Mizugaki's research lab specializes in the development of heterogeneous nanocatalysts for the sustainable conversion of biomass-derived platform chemicals into valuable chemicals and fuels. The lab focuses on designing supported bimetallic and monometallic nanoparticle catalysts—such as Pt on hydrotalcite and Pt–Mo on hydroxyapatite—that enable selective, additive-free transformations under mild, aqueous conditions. Their work emphasizes catalyst design for high activity, selectivity, and recyclability, contributing to green and efficient chemical processes. The research bridges materials science and catalysis to address challenges in renewable resource utilization and environmental sustainability.
Professor Renhua Qiu's research lab specializes in the development of sustainable and efficient catalytic methodologies in organic synthesis, with a strong focus on transition metal and organometallic catalysis. The lab pioneers innovative C–H bond functionalization strategies, particularly for the selective chalcogenation of nitrogen-containing heterocycles such as carbazoles, indoles, and quinolones, using palladium and copper catalysts. A key direction involves designing reusable, air-stable, and highly selective organometallic Lewis acid catalysts—especially bismuth-based systems—that function efficiently in aqueous media, enabling green and diastereoselective transformations. The lab also explores practical, one-pot syntheses of bioactive molecules, such as 3,3'-diindolylmethanes, with demonstrated anticancer properties.
Professor Ho Ngoc Nam's research lab specializes in the design, synthesis, and theoretical investigation of advanced functional materials for energy and catalytic applications. Key research directions include the development of high-entropy alloys, hierarchical porous carbons, and chalcogenide-based thermoelectrics, with a strong emphasis on understanding structure-property relationships at the atomic level. The lab combines first-principles calculations with advanced nanofabrication techniques to engineer materials with enhanced electronic, transport, and catalytic properties.
Professor Kana Fujioka's research lab specializes in experimental and theoretical studies of quantum materials, with a focus on strongly correlated electron systems and functional oxides. The lab investigates electronic structures and optical properties of complex oxides such as SrRuO₃ using advanced spectroscopic techniques like photoemission and x-ray absorption spectroscopy, combined with first-principles calculations. A key research direction involves understanding electron correlation effects in transition metal oxides and their impact on electronic and magnetic properties. Additionally, the lab explores optical materials, particularly deuterated KDP crystals, for applications in ultra-broadband nonlinear optics and laser frequency conversion.
Professor Fei Li's research lab specializes in the design, synthesis, and application of high-entropy materials, with a focus on high-entropy ceramics, ultra-high temperature ceramics (UHTCs), and high-entropy oxides. The lab explores advanced materials for extreme environments, including high-temperature structural components, thermal barrier coatings, and gas sensors, leveraging principles of entropy stabilization and multi-element solid solutions. Key research directions include the development of 2D layered high-entropy materials, defect engineering in wide-bandgap semiconductors, and functional thin films for spintronic and sensing applications.
Professor Kodai Hatta's research lab focuses on the interplay between oral health and age-related physical and cognitive decline in older adults. The lab investigates how oral functions—such as occlusal force, masticatory performance, tongue pressure, and swallowing—impact physical frailty, mobility, and cognitive function in the elderly. Longitudinal studies are central to their work, aiming to identify early oral health indicators of sarcopenia, frailty, and dementia. The lab emphasizes the role of posterior occlusal support and oral function decline as potential predictors of functional and cognitive deterioration in aging populations.
Professor Nobuhiro Matsushita's research lab specializes in the development of advanced functional thin films and nanomaterials for electronic and energy applications. The lab focuses on low-temperature solution-based processes—such as spin-spray plating and wet-chemical deposition—for fabricating high-performance oxide films, including ferrites, ZnO, and SnO₂, with tailored magnetic, electrical, and sensing properties. Key research directions include electromagnetic noise suppression using high-permeability ferrite films, transparent and conductive oxide films for humidity sensing, and defect engineering in complex oxides for enhanced functionality. The lab emphasizes practical applications in microelectronics, flexible devices, and environmental sensors through innovative materials processing at low temperatures.
Professor Keiichi Jingu's research lab specializes in radiation oncology, with a focus on improving local control and survival outcomes for patients with oligometastatic and recurrent cancers. The lab investigates the efficacy of stereotactic body radiotherapy (SBRT) and chemoradiotherapy in treating pulmonary oligometastases from colorectal cancer and recurrent esophageal cancer, emphasizing dose escalation and combination therapies. Key research directions include optimizing radiotherapy protocols, evaluating treatment response, and identifying prognostic factors in challenging clinical scenarios.
Professor Masaaki Nakayama's research lab focuses on molecular mechanisms underlying drug resistance in cancer cells, particularly the regulation of the MDR1 gene and its epigenetic control via DNA methylation. The lab also investigates the pathogenic mechanisms of bacterial toxins, such as Helicobacter pylori's VacA and Porphyromonas gingivalis' gingipains, in promoting cellular injury and inflammation. A key emphasis is placed on signal transduction pathways, including PI3K/Akt/GSK3β and MAPKs, in disease progression. Additionally, the lab explores therapeutic strategies, such as hydrogen-enriched dialysis, to mitigate inflammatory and metabolic complications in renal disease.
Professor Chris J. Pickard's research lab specializes in first-principles computational materials science, focusing on the prediction and understanding of novel electronic, magnetic, and structural properties of materials under extreme conditions. The lab develops advanced density functional theory (DFT) methods for accurate simulation of NMR chemical shifts, EPR g-tensors, and electronic responses in insulators and paramagnetic systems. A central theme is the discovery of new stable phases—especially in hydrogen-rich and light-element materials—using ab initio random structure searching (AIRSS), particularly under high pressure. The lab also investigates high-pressure metallization, superconductivity, and exotic bonding in systems such as silane, nitrogen, and hydrogen.
Professor Daisuke Ando's research lab specializes in advanced lightweight alloys, with a focus on magnesium and aluminum-based materials for structural and energy applications. Key research directions include developing shape-memory and superelastic magnesium alloys, enhancing hydrogen generation through nanostructured Mg–Ca alloys, and improving high-temperature strength in aluminum alloys using machine learning-driven materials design. The lab integrates experimental metallurgy with advanced characterization techniques such as TEM and XRD to understand deformation mechanisms and phase transformations at the microstructural level.
Professor Masatake Kuroha's research lab specializes in gastrointestinal endoscopy and molecular diagnostics, focusing on the development of minimally invasive techniques and biomarkers for early detection of colorectal and gastrointestinal malignancies. The lab investigates exosomal microRNAs as potential diagnostic tools for colorectal adenoma (CRA), explores the impact of pretreatment biopsy on endoscopic submucosal dissection (ESD) outcomes, and examines rare gastrointestinal lymphomas using advanced endoscopic imaging. Their work bridges clinical endoscopy with molecular pathology to improve diagnostic accuracy and procedural efficiency.
Professor Kumi Nakai's research lab specializes in plasma physics and engineering, with a focus on numerical modeling and simulation of dielectric barrier discharge (DBD) and tri-electrode plasma actuators for aerodynamic control and flow manipulation. The lab develops advanced computational models—such as three-fluid plasma models and engineering-level body force representations—to understand and optimize electrohydrodynamic (EHD) force generation and jet formation in plasma actuators. Additionally, the lab applies optimal experimental design and sensor selection techniques to high-dimensional data systems, integrating multi-objective optimization and submodular function theory for efficient data acquisition in seismic and plasma sensing applications.
Professor Yoshio Araki's research lab specializes in glycobiology and host-microbe interactions, with a focus on the structural chemistry of bacterial cell walls, particularly peptidoglycan and teichoic acids in Gram-positive bacteria. The lab investigates enzymatic deacetylation of chitin and chitin derivatives, exploring the roles of these enzymes in microbial metabolism and host immune responses. A central theme is the pathogenesis of inflammatory bowel disease (IBD), using DSS-induced colitis models to dissect the contributions of intestinal mast cells, microbiota, and short-chain fatty acids to mucosal inflammation and barrier integrity. The lab also examines bioactive food components, such as germinated barley foodstuffs, in modulating colonic inflammation through microbial and metabolic pathways.
Professor Zhengshu Zhou's research lab specializes in enterprise architecture, non-functional requirement (NFR) assurance, and the application of architectural frameworks such as ArchiMate in critical domains like healthcare, autonomous systems, and Industry 4.0. The lab focuses on developing quantitative and visual methodologies for system evaluation, particularly in ensuring reliability, security, and service innovation in complex information systems. Research directions include software architecture evaluation, cybersecurity in autonomous vehicles, and the integration of business modeling frameworks to enhance enterprise value creation.
Professor Arata Katayama's research lab specializes in environmental microbiology and bioremediation, focusing on the microbial degradation of persistent organic pollutants such as pesticides, polychlorinated phenols, and organochlorine compounds. The lab investigates anaerobic and aerobic microbial consortia capable of degrading recalcitrant contaminants through reductive dechlorination and mineralization pathways, with particular emphasis on pentachlorophenol (PCP) and endosulfan. Using both laboratory-scale batch systems and continuous-flow bioreactor setups, the lab explores microbial community dynamics, metabolic pathways, and the influence of environmental factors such as electron donors and redox conditions. Their work also includes quinone profiling to assess long-term shifts in soil microbial communities under different agricultural management practices.
