东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Shotaro Hirase's research lab specializes in evolutionary genomics and phylogeography, focusing on marine vertebrates and invertebrates to unravel the mechanisms of speciation, gene flow, and adaptive evolution. The lab employs population genomic approaches, including whole-genome and mitochondrial DNA analyses, to investigate evolutionary processes in marine organisms such as abalones and gobies, particularly in the context of historical biogeography and ecological speciation. A central theme is understanding how genetic diversity and introgression—especially from extinct or unsampled lineages—shape current biodiversity in the Northwest Pacific. The lab also explores the role of structural variants, such as GCNVs, in adaptive evolution.
Professor Sota Fujii's research lab focuses on the molecular mechanisms underlying mitochondrial-nuclear interactions in flowering plants, with a central emphasis on cytoplasmic male sterility (CMS) and fertility restoration. The lab investigates the role of pentatricopeptide repeat (PPR) proteins in regulating mitochondrial RNA metabolism, particularly in controlling the expression and degradation of CMS-associated mitochondrial genes. Using integrative approaches combining genomics, molecular genetics, and reverse genetics, the lab uncovers evolutionary and functional dynamics of mitochondrial genome rearrangements and their impact on plant fertility and development. Their work provides fundamental insights into organelle-nucleus co-evolution and has significant implications for plant breeding and biotechnology.
Professor Kenji M. Matsuzaki's research lab specializes in high-resolution paleoceanographic reconstructions using siliceous microfossils, particularly polycystine radiolarians, to decipher past oceanographic conditions in the North Pacific and marginal seas such as the Japan Sea and the East China Sea. The lab focuses on quantitative temperature reconstructions—especially sea surface and intermediate water temperatures—through transfer function analyses and multivariate statistical methods applied to deep-sea sediment cores and plankton tows. Their work integrates geological, climatological, and oceanographic data to understand the impacts of tectonic evolution, monsoon dynamics, and global climate change on regional ocean circulation over the Neogene and Quaternary periods.
Professor Kazunaga Ishigaki's research lab specializes in gastrointestinal endoscopy and interventional radiology, with a focus on improving diagnostic accuracy and safety in pancreatic and solid organ lesions. The lab investigates advanced needle techniques, such as EUS-Fine Needle Biopsy (EUS-FNB) using 22-gauge Franseen needles, to enhance tissue acquisition and diagnostic yield. It also explores clinical complications like thromboembolism in patients with advanced pancreatic cancer, particularly in relation to liver metastasis and prognosis. The lab’s work bridges interventional endoscopy with oncological outcomes, aiming to optimize patient management through precise, minimally invasive diagnostics.
Professor Rogie Royce Carandang's research lab specializes in aging, mental health, and health policy, with a strong focus on the well-being of older adults and vulnerable populations such as migrant care workers and senior citizens in the Philippines. The lab investigates subjective well-being, unmet health and social needs, and the impact of psychosocial factors on aging populations, particularly through mixed-methods and systematic review approaches. A key direction involves informing policy through evidence-based research on community-based health services and support systems.
Professor Hideki Endo's research lab focuses on translational and clinical research in surgical outcomes, intensive care medicine, and conservation biology. The lab investigates quality improvement in laparoscopic gastrointestinal surgery, develops risk prediction models for critical care patients—particularly during the COVID-19 pandemic—and explores the complex ecological and socio-cultural dynamics between humans and endangered species such as the Komodo dragon in Indonesia. The lab integrates clinical data science with molecular biology, including protein interactions in cell cycle regulation, to address both healthcare quality and biodiversity conservation challenges.
Professor Kensuke Tamura's research lab specializes in quantum many-body physics, combinatorial optimization using Ising machines, and applied physics for medical and astronomical applications. The lab explores quantum phenomena such as SU(n) ferromagnetism and quantum many-body scars in frustrated and correlated fermionic systems, while also developing advanced analog ASICs for high-energy astrophysics and X-ray detection. Additionally, the lab investigates the molecular mechanisms of neurodegenerative diseases, particularly Alzheimer’s disease, through integrative biological and pharmacological approaches. The interdisciplinary work bridges theoretical physics, materials science, and biomedical engineering to address fundamental and applied challenges.
Professor Kaichi Yanaoka's research lab focuses on the development of executive functions and cognitive control in early childhood, with a particular emphasis on how children manage delays in gratification, represent task contexts flexibly, and learn sequential actions. The lab investigates the interplay between cognitive mechanisms—such as working memory, planning, and proactive control—and real-world behaviors like academic success, emotional regulation, and vocabulary acquisition. Using behavioral, pupillometric, and computational modeling approaches, the lab explores how children learn and adapt routines, especially in culturally diverse contexts.
Professor Takeshi Teshima's research lab specializes in statistical machine learning, with a focus on invertible neural networks, domain adaptation, and matrix recovery under non-standard observation models. The lab investigates the theoretical foundations of deep generative models—particularly neural ordinary differential equations and coupling flow-based invertible networks—exploring their universality and approximation properties. A key direction involves developing robust methods for few-shot domain adaptation through novel invariance assumptions, such as mechanism transfer, to handle complex distribution shifts. The lab also contributes to statistical recovery theory, providing guarantees for low-rank matrix completion from clipped observations.
Professor Kazuhiro Fukami's research lab specializes in electrochemical materials synthesis, with a focus on the fundamental mechanisms of electrodeposition processes and the formation of complex nanostructures. The lab investigates dynamic phenomena such as potential oscillations and self-organized growth in electrodeposited systems, leading to ordered dendritic, nanorod, and chiral nanostructures. Key research directions include the controlled fabrication of functional nanomaterials—such as gold nanorod arrays, medium-entropy alloys, and chiral nanostructures—using tailored electrochemical and templated methods.
Professor Masahiro Ehara's research lab specializes in theoretical and computational chemistry, focusing on the electronic structures, reaction mechanisms, and catalytic properties of nanomaterials and surface systems. Key research directions include single-atom and nanocluster catalysis, particularly in environmentally and industrially relevant reactions such as CO oxidation and NO reduction. The lab employs advanced quantum chemical methods—such as DFT, MCTDH, and configuration interaction calculations—to unravel the origins of catalytic activity, selectivity, and chirality at the atomic level. They also investigate molecular interactions at surfaces, including inelastic scattering and core-level spectroscopy, with a strong emphasis on symmetry and electronic dynamics.
Professor Kōichiro Tanaka's research lab specializes in ultrafast nonlinear optics and terahertz science, focusing on the generation and application of intense single-cycle terahertz pulses for probing dynamic processes in condensed matter. The lab investigates nonlinear optical phenomena such as high-harmonic generation in two-dimensional materials like graphene, particularly under intense mid-infrared excitation, and explores quantum mechanical origins of coherent electron dynamics. A key focus is on understanding and manipulating light-matter interactions in semiconductors, including the dynamical Franz-Keldysh effect and coherent control of excitonic systems. The lab also engages in interdisciplinary studies linking optical physics with biomedical applications, such as cytokine production in immune cells, demonstrating a broad scientific scope from fundamental physics to biological sensing.
Professor Nobuyuki Maruyama's research lab specializes in structural and functional analysis of plant storage proteins, particularly soybean beta-conglycinin, with a focus on the roles of post-translational modifications such as N-glycosylation and subunit-specific extension regions in protein stability, solubility, and conformation. The lab investigates the physicochemical properties of recombinant and native protein subunits using techniques like X-ray crystallography, circular dichroism, and size-exclusion chromatography, aiming to understand structure-function relationships in complex multimeric proteins. Additionally, the lab explores allergenic proteins in food, including wheat gluten and sesame, to identify key allergens and improve diagnostic accuracy through recombinant protein expression and IgE reactivity profiling. Their work bridges structural biology, food biochemistry, and clinical allergy research to enhance food safety and allergy diagnostics.
Professor Kazuaki Jindai's research lab specializes in antimicrobial stewardship, infectious disease epidemiology, and public health interventions, with a focus on optimizing antibiotic use in outpatient and community settings. The lab investigates the impact of clinical guidelines, financial incentives, and educational initiatives on antimicrobial prescribing patterns, particularly in aging populations and pediatric patients. It also contributes to global clinical trial networks such as REMAP-CAP to accelerate the discovery of effective treatments for infectious diseases like pneumonia and COVID-19. The lab’s work emphasizes real-world implementation, sustainability of health interventions, and health behavior changes during public health crises.
Professor Fumitaka Ishiwari's research lab specializes in advanced materials chemistry, focusing on the design and synthesis of functional organic and polymer materials with precise molecular control. Key research directions include the development of self-assembled monolayers for surface engineering, stimuli-responsive polymers for sensing applications, and conformationally flexible ladder polymers with dynamic structural behavior. The lab also explores chiral materials and supramolecular architectures, particularly mechanically chiral rotaxanes, to induce and control helical conformations in polymers for optoelectronic and sensing applications.
Professor Takahiko Ban's research lab specializes in chemically driven self-propulsion of soft matter, particularly in aqueous two-phase systems and surfactant-loaded droplets. The lab investigates how interfacial tension gradients, chemical potential differences, and Korteweg forces induce autonomous motion and shape changes in droplets and vesicles. A key focus is on designing stimuli-responsive droplets capable of directional motion in response to pH, metal ions (e.g., Dy³⁺, alkaline-earth metals), and chemical gradients, enabling applications in targeted transport and environmental sensing. The work bridges soft matter physics, interfacial science, and bio-inspired materials design.
Professor Manabu Fujimoto's research lab specializes in autoimmunity, with a focus on identifying and characterizing autoantibodies in autoimmune diseases such as dermatomyositis and the anti-synthetase syndrome. The lab investigates the pathogenic mechanisms underlying these conditions, particularly the role of anti-ARS and anti-TIF-1 antibodies in linking autoimmunity to cancer-associated immune responses. Using serological and molecular approaches, the lab aims to classify autoimmune subtypes based on autoantibody profiles to improve diagnosis, prognosis, and personalized treatment strategies.
Professor Koji Okamoto's research lab focuses on the molecular mechanisms underlying selective autophagy, particularly mitophagy, in yeast and its evolutionary conservation in higher eukaryotes. The lab investigates how cells maintain mitochondrial quality and quantity through organelle-specific degradation pathways, emphasizing the roles of key proteins such as Atg32, Atg11, and autophagy-related complexes in cargo recognition and autophagosome formation. By combining genetic, cell biological, and imaging approaches, the lab aims to decipher the signaling networks and posttranslational modifications that regulate organellophagy in response to stress and metabolic changes. Their work contributes to understanding the pathophysiological implications of defective mitophagy in aging, neurodegeneration, and cancer.
Professor H. Takabe's research lab at the Institute of Laser Engineering (ILE), Osaka University, specializes in theoretical and computational plasma physics, with a focus on inertial confinement fusion, hydrodynamic instabilities such as the Rayleigh–Taylor instability, and ablative stabilization mechanisms. The lab develops advanced integrated simulation codes—like ILESTA—to model complex plasma dynamics in laser-driven fusion targets, including turbulent mixing and non-local electron transport effects. Their work bridges fundamental plasma physics with applications in fusion energy and astrophysical phenomena, such as supernova explosions and self-generated magnetic fields. The lab also investigates the role of magnetic turbulence and collisionless shocks, particularly through the Weibel instability, to understand structure formation in high-energy plasmas.
Professor Zhongyuan Feng's research lab specializes in advanced welding materials and thermal-mechanical modeling, focusing on low transformation temperature (LTT) weld metals to enhance residual stress control and fatigue performance in welded structures. The lab develops innovative LTT welding materials with tailored martensite start temperatures and solidification behaviors to prevent cracking and improve mechanical properties in various welding positions. Through integrated experimental and numerical approaches—including finite element analysis, synchrotron XRD, and in-situ phase evolution observation—the lab advances computational efficiency and predictive accuracy in welding process simulation. Their work bridges materials design, microstructure control, and structural integrity, particularly for critical engineering applications.
