东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Hui Ming Khoo's research lab specializes in epilepsy and neuroimaging, focusing on identifying the neural origins of epileptic activity using advanced multimodal techniques such as EEG-fMRI and stereo-electroencephalography (SEEG). The lab investigates interictal epileptic discharges, seizure onset zones, and functional brain networks—particularly the default mode network—in epilepsy and other neurological disorders like idiopathic normal pressure hydrocephalus (iNHP). A key focus is validating noninvasive methods to localize epileptogenic regions, thereby improving surgical planning and reducing the need for invasive monitoring. The lab also explores the integration of hemodynamic responses with electrophysiological data to map functional brain networks with high precision.
Professor Tatsuhiko Sato's research lab specializes in computational radiation physics, focusing on the development and application of the PHITS (Particle and Heavy Ion Transport code System) code for simulating high-energy particle and heavy ion transport. The lab conducts advanced Monte Carlo simulations to model radiation interactions in various environments, including the Earth's atmosphere, space, and human tissues, with applications in aviation dosimetry, space radiation protection, and hadron therapy. A key focus is the creation of analytical radiation models—such as PARMA—derived from extensive PHITS simulations to enable rapid and accurate estimation of cosmic-ray spectra. The lab also enhances simulation accuracy through continuous code upgrades, improved nuclear reaction models, and integration of advanced computational techniques like track-structure and condense history methods.
Professor Hideaki Sakai's research lab specializes in quantum materials and functional oxides, focusing on the interplay between electronic, magnetic, and structural properties in complex oxides and topological materials. Key research directions include the discovery and manipulation of novel quantum phenomena such as the half-integer quantum Hall effect in Dirac materials and field-tunable magnetoelectric effects in Mott insulators. The lab also investigates biological mechanisms in bone remodeling, particularly the fate of osteoclasts during physiological transitions, using advanced imaging and biochemical techniques. These interdisciplinary efforts bridge condensed matter physics, materials science, and biomedicine.
Professor Takeshi Hatanaka's research lab specializes in distributed control and optimization for networked systems, with a strong emphasis on passivity-based methods, energy management in HVAC systems, and safe control for autonomous robotic systems. The lab focuses on developing robust, scalable algorithms for multi-agent systems—such as drone swarms and human-robot interactions—ensuring stability, synchronization, and safety under communication delays, topology changes, and uncertain environments. Key applications include persistent surveillance missions, human-swarm collaboration, and energy-efficient building control. The integration of passivity theory with optimization and control enables rigorous convergence and robustness guarantees in real-world scenarios.
Professor Motoki Sakaguchi's research lab specializes in the mechanical behavior and fatigue life assessment of advanced high-temperature structural materials, particularly single-crystal Ni-based superalloys used in gas turbines. The lab focuses on fatigue crack propagation, thermo-mechanical fatigue, and microstructure–property relationships under extreme service conditions, with an emphasis on near-threshold crack growth and damage mechanisms. Experimental and computational approaches, including crystal plasticity finite element analysis and miniature specimen testing, are employed to understand and predict component reliability in aero-engine and land-based turbine applications. The lab also explores innovative joining technologies for dissimilar materials, such as dimple spot welding, for lightweight and high-performance structural applications.
Professor Hiroyasu Mochizuki's research lab specializes in advanced thermal-hydraulics and nuclear reactor safety, with a focus on natural circulation flows, heat transfer phenomena in liquid-metal-cooled systems, and transient behavior in advanced nuclear reactors. The lab conducts experimental and computational studies on instability mechanisms in advanced reactors such as the Advanced Thermal Reactor (ATR) and molten chloride salt fast reactors, emphasizing accurate modeling of heat transfer and fluid dynamics under low-flow and passive safety conditions. Their work integrates neutronics and thermal-hydraulics coupling analyses to evaluate intrinsic safety characteristics and fuel temperature responses during transients. The lab also investigates anomalies in heat transfer coefficients at low Péclet numbers, challenging conventional empirical correlations in liquid metal systems.
Professor Kuniyuki Kakushima's research lab specializes in advanced semiconductor materials and nanostructured devices, with a focus on ferroelectric and high-k dielectric materials for next-generation electronic applications. The lab investigates the crystallographic and electronic properties of thin films—such as Sc-doped AlN and lanthanum silicates—using advanced characterization techniques like x-ray photoelectron spectroscopy and hard x-ray photoemission spectroscopy to probe band bending and interfacial chemistry. Their work spans ferroelectric memory devices, high-performance power transistors (e.g., 3D-scaled IGBTs), and interface engineering in metal-oxide-semiconductor systems, aiming to enable energy-efficient and high-density electronic technologies. The lab emphasizes the correlation between material microstructure, electronic band structure, and device performance at the nanoscale.
Professor Itaru Nakamura's research lab specializes in transition-metal-catalyzed organic synthesis, with a strong focus on the development of novel catalytic methods for the efficient construction of heterocyclic and carbocyclic compounds. The lab pioneers the use of gold, palladium, platinum, and other base metals to enable mild, atom-economical cyclization reactions—particularly for synthesizing sulfur- and oxygen-containing heteroarenes such as benzothiophenes and benzofurans. Key innovations include formal [3+2] cycloadditions, metal hydride additions, and intramolecular aminosulfonylation, often under ambient conditions with high functional group tolerance. The group emphasizes synthetic efficiency, step economy, and the use of readily available starting materials, contributing significantly to modern heterocyclic chemistry and drug discovery.
Professor Tomoteru Fukumura's research lab specializes in the development and characterization of magnetic oxide semiconductors for next-generation spintronic devices. The lab focuses on engineering diluted magnetic semiconductors, such as Mn-doped ZnO and transition metal-doped oxides, to achieve high Curie temperature ferromagnetism and electric-field control of magnetism. Key research directions include the synthesis of epitaxial thin films via pulsed-laser deposition, the exploration of carrier-mediated ferromagnetism, and the application of advanced characterization techniques to map structural, magnetic, and electronic phase transitions. The lab also pioneers innovative methods like composition-spread films and electric double-layer gating to accelerate materials discovery and enable room-temperature spintronic functionality.
Professor Masafumi Goto's research lab specializes in translational biomedical research, focusing on overcoming immune barriers in xenotransplantation—particularly the instant blood-mediated inflammatory reaction (IBMIR) triggered by porcine islets during intraportal transplantation. The lab investigates novel pharmacological agents, such as low molecular weight dithiols (LMW-DS) and complement inhibitors like Compstatin, to modulate innate immune responses and improve graft survival. Additionally, the lab explores enzymatic and biochemical mechanisms, including metallo-β-lactamase inhibition, to support broader applications in infection control and drug development. Their work bridges basic biochemistry with clinical applications in diabetes therapy.
Professor Kanjuro Makihara's research lab specializes in smart structural systems with a focus on vibration control, energy harvesting, and piezoelectric actuation. The lab develops innovative semi-active and active control strategies—such as synchronized switch harvesting on inductor (SSHI) and LR-switching—that enhance energy efficiency and vibration suppression in mechanical systems. By integrating self-sensing techniques using Kalman filtering and extended system modeling, the lab enables real-time structural health monitoring and control without external sensors. The research also extends to advanced aerospace applications, including morphing wings and nonlinear dynamic modeling for adaptive aerostructures.
Professor Taku Nonomura's research lab specializes in computational fluid dynamics, with a focus on high-order numerical methods for solving compressible Navier-Stokes equations, particularly in complex flows involving shocks, turbulence, and aeroacoustics. The lab develops advanced numerical schemes—such as weighted compact nonlinear schemes (WCNS), finite-difference WENO, and dynamic mode decomposition (DMD) with Kalman filtering—aimed at achieving high accuracy, stability, and freestream preservation in complex geometries. A key research direction involves the simulation and analysis of supersonic jet flows and their associated acoustic emissions, especially in configurations like jet impingement on inclined plates. The lab also emphasizes system identification and noise reduction in fluid dynamics data through innovative data-driven methods.
Professor Hiroshi Machida's research lab specializes in volcanic and geological sciences, with a primary focus on tephrochronology, volcanic petrology, and the geochemical characterization of Quaternary tephras in Japan. The lab conducts detailed petrographic and refractive index analyses to identify and correlate widespread volcanic ash layers, contributing to regional stratigraphic frameworks and paleoenvironmental reconstructions. Their work also extends to the physical properties of ionic liquids, particularly under extreme conditions, using high-pressure and high-temperature measurements. The integration of field-based tephra studies with laboratory-based analytical techniques defines the lab’s interdisciplinary approach.
Professor Ryoto Inui's research lab specializes in theoretical cosmology, focusing on primordial black hole formation, scalar-induced gravitational waves (SIGWs), and non-Gaussianities in the early universe. The lab employs numerical relativity and statistical field theory to explore the interplay between inflationary dynamics, non-Gaussian curvature perturbations, and gravitational wave signatures. A central theme is the role of logarithmic non-Gaussianities—recently validated in wide classes of inflation models—in shaping PBH formation and detectable gravitational wave backgrounds. The lab also investigates high-frequency gravitational wave signals from exotic early-universe processes, such as graviton bremsstrahlung from superheavy particle production.
Professor Tsuyoshi Inoue's research lab specializes in theoretical and numerical astrophysics, focusing on the role of magnetic fields, turbulence, and shock dynamics in interstellar medium processes. The lab investigates star formation triggers, particularly through shock-compressed molecular clouds and turbulent filament formation, using advanced 3D magnetohydrodynamics (MHD) simulations. Key research directions include magnetic field amplification via turbulent dynamo, thermal instability in weakly ionized plasmas, and the formation of molecular clouds and dense filaments as precursors to star formation. The lab also contributes to observational programs such as the BISTRO survey, linking simulations with submillimeter polarimetry data to probe magnetic field structures in star-forming regions.
Professor Takeru Nose's research spans polymer physics and biophysical chemistry, with a focus on the thermodynamic and dynamic behavior of polymer solutions, particularly phase separation processes and the conformational properties of polymers in solution. His work includes foundational studies on spinodal decomposition and scaling laws in polymer mixtures, as well as investigations into the static and dynamic properties of polystyrene in solvents near the θ condition. Later research extended into bioactive peptide design, particularly the role of aromatic amino acids in receptor activation, demonstrating a shift toward bioorganic applications. His lab has contributed significantly to understanding both fundamental polymer physics and structure-activity relationships in peptide signaling.
Professor Etsuko Tadaka's research lab focuses on promoting the well-being and social health of older adults, particularly those living with dementia. The lab investigates non-pharmacological interventions—such as reminiscence and reality orientation group programs—to maintain cognitive function and daily living abilities. It also explores community-level factors, including self-efficacy, social participation, and social isolation, to develop effective public health strategies for aging populations in Japan and beyond.
Professor Kenji Ogawa's research lab specializes in cognitive neuroscience, focusing on the neural mechanisms underlying sensorimotor control, visuomotor transformation, and language processing. The lab investigates how the brain represents and adapts to sensorimotor mappings, particularly through functional neuroimaging techniques such as fMRI and multivoxel pattern analysis. Key research directions include internal monitoring of self-generated versus externally guided movements, neural substrates of motor learning and adaptation, and cross-linguistic sentence comprehension. The lab also explores developmental and clinical aspects of visuomotor integration using neuroimaging and behavioral studies in both healthy individuals and clinical populations such as those with Williams Syndrome.
Professor Tsutomu Endo's research lab focuses on the pathophysiological mechanisms linking metabolic disorders—particularly dyslipidemia, obesity, and non-alcoholic fatty liver disease (NAFLD)—to spinal ossification disorders such as ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligamentum flavum (OLF). The lab investigates hormonal and lipid metabolism regulation in disease progression, using both clinical data and in vitro models to explore the roles of sex steroids like 11-ketotestosterone and lipoproteins in tissue calcification. A central theme is the intersection of endocrinology, lipid metabolism, and skeletal disorders, with translational research aimed at identifying metabolic risk factors and potential therapeutic targets.
Professor Masaharu Yoshioka's research lab specializes in information retrieval, natural language processing, and intelligent document analysis, with a focus on enhancing the accuracy and usability of legal and news text understanding systems. The lab develops advanced NLP techniques such as BERT-based models, query reformulation methods, and data augmentation strategies to address challenges in low-resource and complex text environments. Key research directions include legal textual entailment, automatic summarization of multi-document news, and the formalization of design and information retrieval knowledge for intelligent systems. The lab emphasizes practical applications in legal technology, news summarization, and knowledge-intensive information systems.
