东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Gaku Tsuji's research lab focuses on the molecular mechanisms underlying atopic dermatitis and psoriasis, with a central emphasis on the role of the aryl hydrocarbon receptor (AHR) in skin barrier function, immune regulation, and inflammation. The lab investigates how AHR ligands—endogenous (e.g., FICZ) and exogenous (e.g., tapinarof, Glyteer)—modulate keratinocyte differentiation, cytokine production (such as IL-1β, IL-24, and IL-31), and dendritic cell function to influence Th2-driven inflammation and pruritus. Key research directions include the genetic and molecular interplay between filaggrin, OVOL1, and AHR in epidermal homeostasis, as well as the therapeutic potential of AHR modulators in inflammatory skin diseases and photo-aging.
Professor Yoshihiro Izumi's research lab specializes in systems biology and metabolomics, focusing on lipid metabolism, extracellular vesicles (EVs), and xenobiotic metabolism in disease contexts such as cancer and liver metabolism. The lab employs advanced analytical techniques—including supercritical fluid chromatography, high-resolution mass spectrometry, and stable isotope labeling—to uncover metabolic dynamics and molecular mechanisms underlying disease progression. Key research directions include the lipidomic profiling of cancer-derived EVs, metabolic kinetics of medium-chain fatty acids, and comprehensive metabolite identification for drug safety and efficacy. The lab also contributes to clinical translational research, particularly in early detection of pancreatic cancer through endoscopic ultrasound and pathological correlation.
Professor Kyoko Hida's research lab focuses on the molecular and cellular mechanisms underlying tumor angiogenesis and the unique properties of tumor endothelial cells (TECs). The lab investigates how TECs differ genetically and functionally from normal endothelial cells, particularly in terms of angiogenic activity, drug resistance, and stem-like characteristics. A central theme is understanding the role of specific molecules—such as CXCR7 and VEGF signaling—in promoting tumor vascularization and therapy resistance, with the goal of developing more effective anti-angiogenic therapies.
Professor Shota Kikuchi's research lab specializes in flavor physics and string theory phenomenology, focusing on modular symmetry as a framework to explain the hierarchical structures of fermion masses and mixing angles in the Standard Model. The lab investigates modular forms on toroidal and orbifold compactifications with magnetic fluxes, exploring how residual symmetries and fixed points of the modular group lead to natural quark and lepton mass hierarchies without fine-tuning. A central theme is the construction of realistic flavor models—particularly using $A_4 imes A_4 imes A_4$ and $ ilde{ m extbackslash{}Gamma}_N$ groups—where mass matrices emerge from modular forms at specific moduli values such as $ au = iar{ extbackslash}infty$ or $ au = ho$. The lab also studies the embedding of these models into higher-dimensional theories, where wave functions in extra dimensions are constrained to transform as modular forms.
Professor Ya-Lun Ho's research lab specializes in nanophotonics and optoelectronics, focusing on the development of advanced photonic devices using solution-processable materials such as perovskite quantum dots and halide perovskites. The lab explores novel concepts like bound states in the continuum (BICs), plasmonic nanolasers, and hot-carrier dynamics to enable compact, high-performance, and chip-integrated light sources and detectors. Key research directions include lithographic integration of perovskites, subwavelength light confinement, and high-sensitivity biosensing through engineered optical resonances. The lab also advances materials engineering for low-loss, high-quality thin films essential for next-generation optoelectronic applications.
Professor Kensuke Miyake's research lab focuses on the molecular mechanisms underlying hematopoietic cell-stromal cell interactions in the bone marrow microenvironment, with a central emphasis on cell adhesion molecules and their roles in lymphopoiesis and myelopoiesis. The lab has made seminal contributions to identifying key adhesion molecules such as CD44/Pgp-1 and VLA-4 (integrin α4β1), and their ligands like hyaluronate and VCAM-1, which regulate lymphoid development and leukocyte trafficking. Using monoclonal antibody-based screening and functional assays, the lab elucidates how these interactions support hematopoietic stem and progenitor cell maintenance and differentiation. The work also extends to understanding the role of innate immune cells, such as basophils, in Th2 immune responses through antigen presentation and cytokine production.
Professor Yang Li's research lab specializes in computational modeling and simulation of biological systems, with a strong focus on organoid technologies, non-rigid 3D shape analysis, and medical imaging. The lab develops advanced deep learning and optimization techniques for 3D point cloud registration, motion estimation in deformable scenes, and the in vitro modeling of human organs—particularly the liver and brain—by integrating stem cell-derived tissues and immune cells. Key research directions include creating functional human organoids for disease modeling, improving non-rigid tracking and reconstruction in dynamic environments, and advancing data-driven methods for incomplete or occluded 3D geometry. The lab bridges computer science, biomedical engineering, and stem cell biology to develop next-generation in vitro models and intelligent algorithms for healthcare applications.
Professor Kenjiro Sawada's research lab focuses on identifying molecular mechanisms driving ovarian cancer progression and metastasis, with a particular emphasis on cell adhesion molecules, growth factor receptors, microRNAs, and signaling pathways such as c-Met, IL-6R, and Rho/ROCK. The lab investigates potential therapeutic targets, including integrins, CD47, and the mevalonate pathway, aiming to develop novel targeted therapies and biomarkers for early diagnosis and personalized treatment. Their work integrates in vitro, in vivo, and clinical validation approaches to translate molecular insights into improved patient outcomes.
Professor Jiaxin Zhang's research lab specializes in urban digital transformation, focusing on the integration of artificial intelligence, remote sensing, and geospatial technologies to address challenges in urban planning, architectural heritage conservation, and smart city development. The lab pioneers AI-driven solutions for urban façade analysis, habitat quality assessment, and building information modeling, with an emphasis on scalable, data-driven methodologies using deep learning, synthetic data, and digital twins. Key research directions include intelligent urban morphology analysis, automated building façade reconstruction, and AI agents for architectural decision-making.
Professor Takahiro Mori's research lab focuses on the molecular mechanisms underlying chronic inflammation and its role in diseases such as rheumatoid arthritis and cancer, with a particular emphasis on signaling molecules like STAT3 and TNFα. The lab also investigates enzymatic pathways involved in natural product diversification, especially prenyltransferases and C-glycoside-degrading enzymes, using structural biology and chemoenzymatic approaches. Their work bridges immunology, cancer biology, and enzymology, aiming to uncover novel therapeutic targets and biocatalytic tools. The lab integrates structural, biochemical, and in vivo studies to explore disease pathogenesis and enzyme function in health and disease.
Professor Titus Masese's research lab specializes in the design and development of advanced functional materials for sustainable energy storage, with a strong focus on potassium-ion and lithium-ion batteries. The lab explores novel electrode materials—particularly layered honeycomb frameworks and nanostructured cathodes—engineered for high-voltage operation, fast ion diffusion, and enhanced electrochemical stability. Key research directions include the discovery of new materials with rich crystal chemistry, the development of high-voltage electrolytes using ionic liquids, and the mechanistic understanding of multi-electron redox reactions in polyanionic compounds.
Professor Kentaro Kaneko's research lab specializes in the epitaxial growth and fundamental characterization of corundum-structured oxide semiconductors, with a focus on wide-bandgap and magnetic semiconductors for next-generation electronic and optoelectronic devices. The lab develops high-quality thin films of α-Ga₂O₃, α-Ir₂O₃, and their solid solutions through advanced mist chemical vapor deposition, enabling applications in high-power, high-voltage, and spintronic devices. Key research directions include bandgap engineering, p-type doping, heterojunction formation, and the exploration of intrinsic ferromagnetism in transition metal-doped oxides.
Professor Hirotsugu Ogi's research lab specializes in advanced ultrasonic and electromagnetic characterization techniques for single-crystalline and anisotropic materials. The lab focuses on the precise determination of elastic, piezoelectric, and internal friction properties using non-contact methods such as resonant ultrasound spectroscopy (RUS) combined with laser-Doppler vibrometry and electromagnetic acoustic resonance (EMAR). Key research directions include overcoming mode identification challenges in resonance spectroscopy and developing contactless, high-precision measurement systems for materials like quartz, langasite, lithium niobate, and copper. The lab's work enables accurate, simultaneous extraction of multiple material coefficients essential for advanced sensor and actuator applications.
Professor Chihiro Tanikawa's research lab specializes in computational orthodontics and craniofacial morphology, focusing on the application of artificial intelligence to improve the accuracy of cephalometric analysis and facial profile prediction. The lab develops AI-driven systems for automatic landmark detection on cephalometric radiographs, with particular emphasis on patient-specific applications, including those with cleft lip and/or palate. Their work integrates confidence-based evaluation methods and 3D facial analysis to enhance surgical outcome assessment and treatment planning.
Professor Yang Ju's research lab specializes in the intersection of biomaterials, nanotechnology, and advanced characterization techniques. The lab investigates how mechanical and topographical cues regulate stem cell fate—particularly mesenchymal stem cells—toward tendon/ligament differentiation, with a focus on signaling pathways like RhoA/ROCK and FAK. It also develops non-contact and high-resolution electrical and microwave-based inspection methods for semiconductor wafers and electronic packages, enabling precise conductivity and defect detection. Additionally, the lab pioneers novel microfabricated probes and cold bonding technologies for next-generation electronics with improved reliability and sustainability.
Professor R. Takagi's research lab specializes in the physics of topological magnetic textures, particularly magnetic skyrmions and their emergent spin phenomena. The lab investigates the formation mechanisms, dynamic properties, and topological stability of skyrmions in chiral and noncentrosymmetric magnetic materials, with a focus on understanding the roles of Dzyaloshinskii-Moriya interaction, magnetocrystalline anisotropy, and spin wave dynamics. Using advanced techniques such as resonant soft X-ray scattering, Lorentz microscopy, and spin-wave spectroscopy, the lab explores skyrmion lattice transformations, magnonic excitations, and spin current generation in quantum materials. Their work bridges fundamental magnetism with potential applications in spintronics and low-power information technologies.
Professor Osamu Sugino's research lab specializes in first-principles electronic structure calculations and quantum dynamics simulations, focusing on materials properties, phase stability, and electron-proton transfer processes at complex interfaces. The lab develops advanced computational methodologies within time-dependent and static density functional theory to study electron dynamics, defect physics, and electrochemical reactions in semiconductors and catalytic systems. Key research directions include the thermodynamic and kinetic behavior of materials under extreme conditions, such as pressure and temperature, and the microscopic mechanisms of hydrogen adsorption and multistep electron/proton transfer in energy-relevant systems. The lab also bridges theory and experiment by validating simulations against spectroscopic and electrochemical data, particularly in the context of electrocatalysis and semiconductor defects.
Professor Hiroshi Suzuki's research lab focuses on molecular mechanisms underlying aging, cancer biology, and post-transcriptional gene regulation. Key research directions include the role of TGF-β and senescence in aging and age-related pathologies, the function of ABCG2 in transporting sulfated conjugates, and the regulatory roles of microRNAs in cancer initiation, progression, and tumor microenvironment crosstalk. The lab also investigates oncogenic miRNAs such as miR-135b in lymphoma pathogenesis, particularly in NPM-ALK-driven anaplastic large cell lymphoma.
Professor Tadashi Matsuda's research lab focuses on the molecular mechanisms underlying cytokine and growth factor signaling, particularly the cross-talk between TGF-beta, IL-6, and estrogen receptor pathways in immune regulation, fibrosis, and cancer. The lab investigates key signaling molecules such as Smads, STAT3, Tyk2, and gp130 in the context of inflammation, tissue repair, and autoimmune diseases. A central theme is the identification of novel regulatory proteins—like PDLIM2 and PIASy—that control transcription factor activity through ubiquitination and protein-protein interactions. The lab integrates molecular biology, cell signaling, and in vivo disease models to uncover therapeutic targets for inflammatory and fibrotic disorders.
Professor Junichi Takagi's research lab specializes in structural biology and molecular mechanisms underlying integrin function, with a focus on how conformational changes regulate ligand binding and cell adhesion. The lab investigates the structural basis of integrin activation, particularly in immune and platelet cells, using advanced techniques such as cryo-electron microscopy, X-ray crystallography, and NMR. A key research direction involves understanding the role of sorting receptors like SORLA in neurodegenerative diseases, especially Alzheimer’s disease, where they modulate amyloid-β production. The lab also explores the molecular determinants of integrin ligand specificity and signaling through domain-swapping and mutagenesis studies.
