东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Kiyotaka Nakagawa's research lab specializes in the bioavailability, metabolism, and physiological effects of bioactive phytochemicals, particularly polyphenols and other plant-derived compounds. The lab focuses on understanding the absorption, distribution, and antioxidant mechanisms of compounds such as green tea catechins (e.g., EGCg), luteolin, sulforaphane, astaxanthin, and 1-deoxynojirimycin in both animal models and human subjects. Using advanced analytical techniques like CL-HPLC, HILIC-MS, and ELSD, the lab investigates the pharmacokinetics and health-promoting potential of these compounds in relation to chronic diseases such as cancer, diabetes, and dementia.
Professor Katsuki Kimura's research lab specializes in membrane technology for water and wastewater treatment, with a primary focus on understanding and mitigating membrane fouling—particularly irreversible fouling—through fundamental studies on membrane and organic matter interactions. The lab investigates advanced processes such as membrane bioreactors (MBRs), direct membrane filtration (DMF), and chemical enhanced backwashing (CEB) to improve membrane stability and longevity in real-world applications. Their work also includes the removal of emerging contaminants like pharmaceuticals from municipal wastewater using analytical techniques such as GC/MS, aiming to enhance treatment efficiency and sustainability. The lab's research bridges materials science, environmental engineering, and water resource management to develop practical, scalable solutions for sustainable water treatment.
Professor Kazuaki Taguchi's research lab specializes in the development of advanced biomaterials for medical applications, with a primary focus on protein-based drug and gene delivery systems. The lab explores the use of natural plasma proteins—particularly albumin and hemoglobin—as versatile platforms for creating safe, efficient, and targeted therapeutics. Key research directions include designing novel liposomal and nanoparticle systems that enhance drug circulation time, improve tumor targeting, and modulate immune responses through macrophage polarization. The lab also investigates artificial oxygen carriers for transfusion alternatives, aiming to overcome limitations of current blood products.
Professor Masanobu Nakayama's research lab specializes in materials science and solid-state ionics, focusing on the fundamental mechanisms of ion transport in oxide and polymer-based electrolytes for next-generation energy storage devices. The lab employs first-principles calculations and advanced electrochemical characterization techniques such as X-ray absorption spectroscopy and AC impedance spectroscopy to investigate defect chemistry, interfacial reactions, and lithium-ion diffusion in cathode and solid electrolyte materials. Key research directions include optimizing solid-state batteries—particularly all-solid-state lithium polymer batteries—through tailored electrolyte design and understanding the electronic and ionic transport properties in complex oxides like doped ceria and olivine-type phosphates.
Professor Atsushi Suzuki's research lab specializes in biomechanics and structural engineering, focusing on muscle fiber type composition in animal skeletal muscles and the mechanical behavior of structural components in steel-concrete composite systems. The lab investigates myofiber heterogeneity in avian and mammalian muscles using histochemical techniques, while also exploring the performance of shear connectors—particularly perfobond connectors—under cyclic loading conditions. A key emphasis is placed on improving the seismic resilience of steel-concrete composite structures, especially in buckling-restrained braced frames, by evaluating stress transfer mechanisms and component-level behavior under reversed cyclic forces.
Professor Yuki Hattori's research lab focuses on the developmental biology and immunology of microglia and myeloid cells in the central nervous system, particularly their roles in brain development and innate immune responses. The lab investigates how microglia dynamically interact with neural progenitor cells and postmigratory neurons through chemokine-guided migration, especially via the CXCL12-CXCR4 axis, and how these interactions influence neuronal differentiation and cortical organization. Additionally, the lab explores the recognition of mycobacterial lipids by innate immune receptors such as Mincle, contributing to understanding of pathogen-associated molecular patterns and their immunomodulatory functions. The research integrates advanced imaging techniques, genetic labeling, and in vitro models to dissect cell fate, migration, and signaling in neural and immune microenvironments.
Professor Toyoshi Yanagihara's research lab focuses on the immunological and molecular mechanisms underlying interstitial lung diseases, particularly idiopathic pulmonary fibrosis (IPF) and immune checkpoint inhibitor (ICI)-induced lung injury. The lab investigates key cellular and signaling pathways—such as amphiregulin, TGF-β1, and immune checkpoint molecules—involved in epithelial cell apoptosis, fibrotic remodeling, and immune cell dysregulation. Utilizing advanced techniques like mass cytometry, ex vivo lung slices, and patient-derived samples, the lab aims to identify novel therapeutic targets and improve preclinical models for drug development. Their work bridges translational immunology with precision medicine in fibrotic and inflammatory lung disorders.
Professor Tomoyoshi Nozaki's research lab specializes in molecular parasitology and cell biology, focusing on the evolution and function of organelles in anaerobic eukaryotic parasites, particularly Entamoeba histolytica. The lab investigates mitochondrion-related organelles such as mitosomes and hydrogenosomes, exploring their proteomic composition, metabolic roles, and evolutionary origins in oxygen-limited environments. Key research directions include the biogenesis and maturation of phagosomes, iron-sulfur cluster assembly, and the unique cysteine biosynthesis pathway in these parasites. The lab employs integrative approaches combining proteomics, cell biology, and molecular genetics to decipher fundamental cellular processes in parasitic protists.
Professor Koichiro Yasaka's research lab specializes in medical image analysis and artificial intelligence, focusing on advancing diagnostic accuracy in abdominal and neurological radiology using deep learning and quantitative imaging techniques. The lab investigates the application of convolutional neural networks (CNNs) for liver mass characterization, fibrosis staging, and improved image reconstruction, particularly in CT and MR imaging. Key research directions include radiomics, image noise reduction, and the development of AI tools to support radiologists in clinical decision-making. The lab also explores the impact of imaging protocols and reconstruction methods on texture analysis and diagnostic performance.
Professor Fan-Yan Wei's research lab focuses on the molecular mechanisms of RNA modifications and their roles in gene expression regulation, metabolism, and neurological disorders. The lab investigates tRNA modifications—particularly methylthiotransferase and 2'-O-methyltransferase enzymes—linking these modifications to diseases such as type 2 diabetes, obesity, and X-linked intellectual disability. A central theme is how post-transcriptional RNA modifications fine-tune translation fidelity and efficiency, impacting cellular physiology and disease pathogenesis. The lab integrates biochemical, genetic, and omics approaches to dissect the functional consequences of RNA modifications in vivo and in disease models.
Professor Nobuhisa Yoshikawa's research lab focuses on innovative therapeutic strategies for gynecological malignancies, particularly ovarian and endometrial cancers. The lab investigates plasma-activated medium (PAM) as a novel, non-thermal atmospheric pressure plasma-based therapy with anti-tumor and anti-metastatic effects, emphasizing mechanisms such as autophagy induction and immune modulation. Additionally, the lab explores molecular-targeted agents like PRIMA-1MET for p53-mutant epithelial ovarian cancer and evaluates prognostic biomarkers such as the prognostic nutritional index (PNI) and performance status (PMI) in early- and advanced-stage gynecological cancers. The overarching goal is to translate preclinical findings into clinical applications for improved patient outcomes.
Professor Masato Nagino's research lab specializes in hepatobiliary and pancreatic surgery, with a primary focus on biliary tract cancers—particularly hilar cholangiocarcinoma and bile duct cancer. The lab investigates surgical strategies, including aggressive resection with vascular reconstruction, to improve long-term survival outcomes. It also explores the biological and physiological impacts of biliary obstruction, such as intestinal barrier dysfunction, and evaluates the benefits of bile replacement during biliary drainage. The lab is deeply involved in evidence-based clinical guidelines development to standardize and optimize patient management.
Professor Toshiro Matsui's research lab specializes in the identification and characterization of bioactive natural compounds, particularly polyphenols such as anthocyanins, flavonoids, and phenolic acids, with a focus on their alpha-glucosidase (AGH) inhibitory activities. The lab investigates the postprandial blood glucose-lowering effects of these compounds using in vitro enzyme assays and in vivo animal models, aiming to develop functional foods or nutraceuticals for the prevention and management of type 2 diabetes. A key research direction involves structure-activity relationships of acylated anthocyanins and theaflavins, especially their selective inhibition of maltase over sucrase, which mimics physiological conditions in the small intestine.
Professor Mitsuhiro Terakawa's research lab specializes in laser-based materials processing for sustainable electronics and biomedical applications. The lab focuses on femtosecond and nanosecond laser technologies to enable precise, chemical-free modification of biodegradable polymers and natural biomaterials, such as cellulose nanofibers and poly(lactic acid). Key research directions include laser-induced graphitization for creating conductive carbon structures, laser-mediated gene transfection for targeted therapy, and the development of biodegradable, metal-free triboelectric nanogenerators for eco-friendly electronics. The lab integrates advanced laser processing with materials science to advance green electronics and tissue engineering.
Professor Kosuke Fukui's research lab specializes in quantum information science and technology, with a focus on fault-tolerant quantum computation using continuous-variable systems. The lab develops innovative quantum error correction schemes, particularly leveraging Gottesman-Kitaev-Preskill (GKP) qubits to enhance noise tolerance and scalability in optical quantum computing. Key research directions include the generation and manipulation of non-Gaussian states, deterministic entangling operations via Gaussian interactions, and efficient design of quantum circuits for large-scale quantum networks and computation. The lab also pioneers hybrid digital-analog error correction and advanced simulation techniques to overcome computational bottlenecks in quantum state engineering.
Professor Takato Mitsudome's research lab specializes in the design and development of advanced heterogeneous nanocatalysts for sustainable organic transformations. The lab focuses on creating core–shell and supported nanoparticle systems—particularly using hydrotalcite, ceria, and noble metals like Ag, Au, Pd, and Cu—for selective and efficient catalytic reactions such as dehydrogenation, oxidation, and hydrogenation under mild, additive-free, or oxidant-free conditions. A key research direction involves engineering interfacial sites between metal cores and oxide shells to enhance selectivity and activity, enabling high turnover numbers and reusability. The lab’s work emphasizes green chemistry principles, aiming to replace stoichiometric oxidants and harsh reaction conditions with reusable, earth-abundant, or base-metal-based catalysts.
Professor Ludovico Minati's research lab specializes in non-invasive neuroimaging and neurophysiological assessment, focusing on brain function, metabolism, and connectivity in aging, neurodegenerative disorders, and cerebrovascular disease. The lab employs advanced neuroimaging techniques such as MRI, MRS, fMRI, DTI, and NIRS to investigate neural substrates of cognition, cardiorespiratory control, and biomarkers of brain health and pathology. A central theme is the translation of neuroimaging findings into clinical applications, particularly in understanding and diagnosing conditions like Alzheimer’s disease and stroke. The lab also explores the neural mechanisms underlying controlled breathing and its physiological effects, bridging neuroscience with autonomic regulation.
Professor Toru Hisabori's research lab focuses on redox regulation in photosynthetic organisms, particularly the molecular mechanisms underlying thioredoxin-dependent regulation in chloroplasts and cyanobacteria. The lab investigates redox-sensitive proteins, including those involved in photosynthetic electron transport, antioxidant defense, and enzyme activation, using biochemical and genetic approaches. A key focus is the identification and characterization of thioredoxin target proteins through innovative techniques like thioredoxin affinity chromatography, enabling the mapping of redox networks in chloroplasts and cyanobacteria. The lab also explores genetic tools for metabolic engineering in cyanobacteria to enhance the production of nitrogenous compounds and other valuable metabolites.
Professor Hirohisa Watanabe's research lab specializes in neurodegenerative disorders, with a focus on atypical parkinsonism, particularly multiple system atrophy (MSA) and dementia with Lewy bodies (DLB). The lab investigates the neuroimaging and neurochemical markers—such as cardiac MIBG scintigraphy and proton magnetic resonance spectroscopy (1H-MRS)—that enable early diagnosis and understanding of disease progression. Their work emphasizes the role of sympathetic nervous system dysfunction and neuronal metabolic changes in neurodegeneration.
Professor Kazuno Negishi's research lab specializes in retinal neurophysiology and ophthalmic optics, focusing on the neural mechanisms underlying visual processing in the retina and the optical performance of intraocular lenses (IOLs). The lab investigates how neurotransmitters such as catecholamines modulate retinal horizontal cells, particularly in fish models, to understand neuromodulation in retinal circuits. Additionally, the lab examines longitudinal chromatic aberration in IOL materials and its impact on retinal image quality, aiming to improve clinical outcomes in cataract surgery. These interdisciplinary studies bridge cellular neuroscience and biophotonics to advance visual function restoration.
