Akifumi Yogo

We report the demonstrated irradiation effect of laser-accelerated protons on human cancer cells. In vitro (living) A549 cells are irradiated with quasimonoenergetic proton bunches of 0.8–2.4 MeV with a single bunch duration of 15 ns. Irradiation with the proton dose of 20 Gy results in a distinct formation of γ-H2AX foci as an indicator of DNA double-strand breaks generated in the cancer cells. This is a pioneering result that points to future investigations of the radiobiological effects of la

Duration-controlled amplified spontaneous emission with an intensity of 10(13) W/cm(2) is used to convert a 7.5-microm -thick polyimide foil into a near-critical plasma, in which the p -polarized, 45-fs , 10(19) -Wcm (2) laser pulse generates 3.8-MeV protons, emitted at some angle between the target normal and the laser propagation direction of 45 degrees . Particle-in-cell simulations reveal that the efficient proton acceleration is due to the generation of a quasistatic magnetic field on the t

Human cancer cells are irradiated by laser-driven quasimonoenergetic protons. Laser pulse intensities at the 5×1019 W/cm2 level provide the source and acceleration field for protons that are subsequently transported by four energy-selective dipole magnets. The transport line delivers 2.25 MeV protons with an energy spread of 0.66 MeV and a bunch duration of 20 ns. The survival fraction of in vitro cells from a human salivary gland tumor is measured with a colony formation assay following proton

Using one of the world most powerful laser facility, we demonstrate for the first time that high-contrast multi-picosecond pulses are advantageous for proton acceleration. By extending the pulse duration from 1.5 to 6 ps with fixed laser intensity of 10¹⁸ W cm^-2, the maximum proton energy is improved more than twice (from 13 to 33 MeV). At the same time, laser-energy conversion efficiency into the MeV protons is enhanced with an order of magnitude, achieving 5% for protons

Fast protons are observed by a newly developed online time-of-flight spectrometer, which provides shot-to-shot proton-energy distributions immediately after the irradiation of a laser pulse having an intensity of ∼1018W∕cm2 onto a 5-μm-thick copper foil. The maximum proton energy is found to increase when the intensity of a fs prepulse arriving 9ns before the main pulse increases from 1014 to 1015W∕cm2. Interferometric measurement indicates that the preformed-plasma expansion at the front surfac

Experiments identify the mechanism that accelerates ions in a laser-driven neutron source (LDNS) as well as a scaling law for the neutron yield, key insights that move LDNS closer to practical neutron generation.

Abstract Thermal neutron (∼25 meV) beam is a powerful tool for investigating the structure and properties of materials used in science and technology. A laser-driven neutron source generating 10 10 neutrons within 1 ns duration is utilized to a single shot radiography with a dual beam of thermal neutrons and X-rays. As a proof of principle, we show the non-destructive inspection of hazardous substances (Cadmium) contained in a typical battery, when the cadmium anode thickness is evaluated from t

Abstract Laser-driven neutron source (LDNS) is attracting interest for several reasons including (i) compactness of the source, (ii) neutron pulse shortness and (iii) transportability of laser beam. Through reviewing recent activities, we discuss the characteristics of LDNS in a comparison with accelerator-based neutron facilities (ABNF). Especially, we discuss the potential and limit of LDNS by showing that neutrons ranging from meV to MeV in energy were generated by LDNS and applied to neutron