Akihito Hashidzume

This minireview overviews rotaxanes and pseudorotaxanes containing cyclodextrins (CDs) as the rotor component. Since CDs interact with molecules, e.g., hydrophobic compounds of the size and shape matching their cavity, to form inclusion complexes in aqueous media, CDs are an important class of macrocyclic compounds as rotor components of rotaxanes and pseudorotaxanes. Research on CD‐based rotaxanes has begun with the synthesis of rotaxanes from low molecular weight axis molecules and then develo

This review article describes the interaction of cyclodextrins (CDs) with polymer side chains as model systems for biological molecular recognition, focusing on the steric effect of the polymer chains, the effect of the conformation of the polymer main chain or competition with association of polymer side chains, and the effect of multi-site interaction. Some typical examples of stimuli-responsive systems, nanoparticles for drug delivery systems and macroscopic self-assembly based on the interac

This article demonstrates that the interaction of cyclodextrins (CDs) with side chains of water soluble polymers is useful not only as simple models for biological molecular recognition but also as building blocks in nanotechnological applications. In the interaction of CDs with polymer side chains, the selectivity of CDs was enhanced by the steric effect of the polymer main chain and by interaction at multi-sites (i.e., collectivity). Utilizing the interaction of CDs with polymer side chains, s

Amphiphilic statistical copolymer samples of sodium 2-(acrylamido)-2-methylpropanesulfonate and n-hexyl methacrylate with different degrees of polymerization and compositions were prepared by reversible addition−fragmentation chain transfer copolymerization, and their self-aggregating structure in 0.1 M aqueous NaCl was studied by light scattering, fluorescence, viscometry, and size exclusion chromatography. Major components of the copolymer samples were aggregates consisting of 2−7 polymer chai

The interactions of polyacrylamide- (pAAm-) based gels possessing cyclodextrin (CD) residues (CD-gels) with pAAm-based gels modified with aromatic residues through amide and ester linkages (ArA-gels and ArE-gels, respectively) were investigated to examine the effect of linkage (i.e., amide and ester) between aromatic residues and the pAAm gel scaffold. In the present study, benzyl (Bz), 2-naphthylmethyl (Np), 9-phenanthrylmethyl (Ph), and 1-pyrenylmethyl (Py) residues were chosen as a series of

Interactions of random copolymers of sodium 2-(acrylamido)-2-methylpropanesulfonate and N-dodecylmethacrylamide (DodMAm) with n-dodecyl hexaethylene glycol monoether (C12E6) with and without added n-hexadecyltrimethylammonium chloride (CTAC) in 0.2 M NaCl aqueous solutions were investigated by fluorescence and light-scattering techniques. The polymers with the DodMAm contents (fDod) ranging from 10 to 50 mol % were singly labeled with pyrene (1 mol %) or doubly labeled with pyrene (1 mol %) and

Abstract Summary: The interaction of a polymer bearing β ‐cyclodextrin moieties ( β ‐CD polymer) with poly(acrylamide)s bearing aromatic side chains was investigated by viscometry to study the effect of collectivity (i.e., interactions at multi‐sites) in macromolecular recognition. The formation of inclusion complexes at multi‐sites caused a large difference in the size of interpolymer aggregates, even though the difference in association constants for complexation of native β ‐CD with guest moi