北海道大学 · 環境科学
阿部敦子教授の研究室では、環境中に広がる化学物質、特にホルムアルデヒドやホスフェートエステル系フラムレジステント（PFRs）、フタレートエステル（Phthalates）などの内分泌攪乱物質にさらされる環境と健康の関連を、主に住環境と妊婦・乳児の健康を対象として研究しています。特に、室内ダスト中の化学物質濃度と喘息・アレルギー疾患の関連、および胎児期の内分泌攪乱物質曝露が新生児のホルモンレベルに与える影響を疫学的手法を用いて解明しています。近年では、複数の化学物質の複合的影響についても注目しており、環境要因と健康リスクの複雑な関係を解明することを目指しています。
Figures are computed from collected data and may differ slightly.
Organophosphate esters are used as additives in flame retardants and plasticizers, and they are ubiquitous in the indoor environment. Phosphorus flame retardants (PFRs) are present in residential dust, but few epidemiological studies have assessed their impact on human health. We measured the levels of 11 PFRs in indoor floor dust and multi-surface dust in 182 single-family dwellings in Japan. We evaluated their correlations with asthma and allergies of the inhabitants. Tris(2-butoxyethyl) phosp
Prenatal di(2-ethylhexyl) phthalate (DEHP) exposure can produce reproductive toxicity in animal models. Only limited data exist from human studies on maternal DEHP exposure and its effects on infants. We aimed to examine the associations between DEHP exposure in utero and reproductive hormone levels in cord blood. Between 2002 and 2005, 514 pregnant women agreed to participate in the Hokkaido Study Sapporo Cohort. Maternal blood samples were taken from 23-35 weeks of gestation and the concentrat
Significant associations of mixed exposures to phthalates and PFRs and increased prevalence of rhinoconjunctivitis was found among elementary school-aged children in the WQS positive model. Mixed exposures were not associated with any of allergic symptoms in the WQS negative model or qg-computation approach. However, the combined effects of exposure to two PFRs suggested an additive and/or multiplicative interaction, potentially increasing the prevalence of rhinoconjunctivitis. A further study w
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