Nagoya University · Medicine
아츠시 에노모토 교수의 연구실은 신장 질환에서의 유미카 토크신 및 대사 물질의 세포 내 이동 메커니즘을 중심으로, 특히 유기산 수송체와 세포 골격 조절 단백질의 기능을 규명하고 있습니다. 인도올 실파이드와 같은 유미카 토크신의 신장 독성 메커니즘과 l-카니틴의 정자 운동성 유도를 위한 세포 내 수송 메커니즘을 분석하며, 세포 이동성과 신호 전달 조절에 핵심적인 역할을 하는 Girdin 단백질의 기능을 연구하고 있습니다. 이는 만성 신부전 및 생식 기능 저하의 병태생리 기전 규명에 기여하고 있습니다.
Figures are computed from collected data and may differ slightly.
In uremic patients, various uremic toxins are accumulated and exert various biologic effects on uremia. Indoxyl sulfate (IS) is one of uremic toxins that is derived from dietary protein, and serum levels of IS are markedly increased in both uremic rats and patients. It has been previously reported that the accumulation of IS promotes the progression of chronic renal failure (CRF). This study demonstrates the role of rat organic anion transporters (rOATs) in the transport of IS and the induction
l-Carnitine is an essential component of mitochondrial fatty acid beta-oxidation and plays a pivotal role in the maturation of spermatozoa within the male reproductive tract. Epididymal plasma contains the highest levels of l-carnitine found in the human body, and initiation of sperm motility occurs in parallel to l-carnitine increase in the epididymal lumen. Using a specific carrier, epididymal epithelium secretes l-carnitine into the lumen by an active transport mechanism; however, the structu
Girdin (GIRDers of actIN filament, also reported as APE, GIV, or HkRP1) is a novel protein expressed ubiquitously in mammals and was recently identified as a binding partner of the serine/threonine kinase Akt. We found that Girdin is an actin-binding protein involved in both the remodeling of the actin cytoskeleton and in cell motility. Recent studies have uncovered new and varied functions of Girdin. For example, it prolongs the activation of Akt and regulates DNA replication in response to ins
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