東北大学 · 医学
東田厚史教授の研究室では、神経変性疾患、特にパーキンソン病における嗅覚障害の神経画像学的・代謝的基盤を解明することを主眼としています。特に、18F-フロルデオキシグルコースを用いた脳代謝イメージングと嗅覚機能評価の統合的解析により、嗅覚障害と脳の代謝異常との関連を解明しています。また、遺伝性疾患の遺伝子解析にも取り組み、チロシナーゼ欠損型眼皮膚白皮症の原因遺伝子を同定する研究も実施しています。
Figures are computed from collected data and may differ slightly.
Hyposmia is one of the cardinal early symptoms of Parkinson disease (PD). Accumulating clinical and pathological evidence suggests that dysfunction of the olfactory-related cortices may be responsible for the impaired olfactory processing observed in PD; however, there are no clear data showing a direct association between altered brain metabolism and hyposmia in PD. In this study, we evaluated brain glucose metabolism and smell-identification ability in 69 Japanese patients with nondemented PD.
Tyrosinase-negative oculocutaneous albinism (OCA) is one of classical inborn errors of metabolism, characterized by a complete lack of melanin pigments in the eyes and skin. We have isolated and characterized the tyrosinase gene of one child (F. S.) affected with tyrosinase-negative OCA. Sequence analysis reveals a single-base mutation in the exon 1 (a G to A transition at nucleotide residue 312), causing the Arg (CGG) to Gln (CAG) substitution at position 59. This base change eliminates one Msp
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