Sungkyunkwan University · 医学
Professor Byoung Joon Kim's research lab specializes in neurological disorders, with a focus on neurodegenerative diseases such as multiple system atrophy and Parkinson’s disease, as well as autoimmune conditions like neuromyelitis optica spectrum disorder (NMOSD). The lab investigates autonomic dysfunction and its clinical correlates in parkinsonism, utilizing tools like the COMPASS-31 questionnaire and objective autonomic testing. It also explores the role of vitamin D in disease activity and disability progression in NMOSD, highlighting the intersection of immunology and neurology. The lab emphasizes translational research, aiming to improve diagnostic accuracy and patient outcomes through biomarker discovery and clinical phenotyping.
Figures are computed from collected data and may differ slightly.
Differentiation of multiple system atrophy with predominant parkinsonism (MSA-P) and Parkinson's disease (PD) is important, but an effective tool for differentiation has not been identified. We investigated the efficacy of the composite autonomic symptom scale 31 (COMPASS 31) questionnaire as a tool for evaluating autonomic function in parkinsonism patients. In this study, we enrolled drug-naïve patients with MSA-P and PD, and administered the COMPASS-31 and an objective autonomic dysfunction te
Patients with autoimmune disorders often have low levels of 25-hydroxyvitamin D [25(OH)D3], which correlates with disability or disease activity. Vitamin D may play a role in neuromyelitis optica (NMO) or NMO spectrum disorder (NMOSD), as an important factor involved in immunological pathways. We investigated the relationship between vitamin D levels and disease related disability and clinical activity in patients with NMOSD. Blood samples from 51 patients with NMOSD who were positive for anti-a
이 논문은 지난 20년간(2000∼2019) 간행된 한국 현대문학 분야 박사학위 논문 서지 데이터를 기반으로, 그간의 현대문학 연구의 변화를 분석ㆍ평가하고 앞으로의 연구를 전망한 것이다. 이를 위해 우선 RISS와 국회도서관에서 논문의 제목, 목차, 초록, 출판연도, 저자 등의 사항을 크롤링하여 기술적 분석을 시도했다. 또한 한국어 형태소 분석기를 통해 명사를 추출하여 키워드 분석과 시계열 토픽 모델링(Dynamic topic model)을 시도했다. 분석 결과, 2000∼19년 사이 현대문학 분야의 박사학위 논문이 20여 개 주요 대학(특히 수도권) 중심으로 배출되었으며, 2010년대 이후 점차 줄어들고 있다는 사실을 확인할 수 있었다. 또한 한국 현대문학 분야에서 전통적인 작가론ㆍ작품론과 시(인) 연구가 여전히 가장 큰 비중을 차지하고 있었다는 것도 알 수 있었다. 문화론, 비교문학, 페미니즘에 근거한 연구들은 점점 더 높은 비중을 차지해오고 있다고 말할 수는 있다. 이상과 같은
The MG-ADL-K is a valid tool and the sMG-ADL-K shows excellent correlation with pMG-ADL-K. Both the pMG-ADL-K and sMG-ADL-K can be used to measure MG severity. Muscle Nerve 57: 419-422, 2018.
Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is underdiagnosed and difficult to treat. Questionnaires based on self-reported symptoms have improved diagnosis and management of neuropathic pain. Visual analog scale and numeric rating scale are most well-known unidimensional pain questionnaires. Multidimensional questionnaire or specialized questionnaire for neuropathic pain are more useful to diagnose neuropathic pain. Screening questionnaires help to identif
Hereditary Spastic Paraplegias (HSP) are a group of rare inherited neurological disorders characterized by progressive loss of corticospinal motor-tract function. Numerous patients with HSP remain undiagnosed despite screening for known genetic causes of HSP. Therefore, identification of novel genetic variations related to HSP is needed. In this study, we identified 88 genetic variants in 54 genes from whole-exome data of 82 clinically well-defined Korean HSP families. Fifty-six percent were kno
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