Korea University · 医学
Professor Cheolmin Shin's research lab focuses on the epidemiology, biomarkers, and neurobiological mechanisms underlying mood and neuropsychiatric disorders, with a strong emphasis on depression. The lab investigates the validity and utility of screening tools like the PHQ-9 and PHQ-8 in national population surveys, contributing to public health understanding of depression prevalence in Korea. It also explores emerging pathways such as the microbiota-gut-brain axis and the glutamatergic system as potential targets for novel antidepressant treatments. Additionally, the lab develops and validates culturally adapted psychological scales, such as the Korean version of the PTED Scale, to assess emotional responses like embitterment in clinical and community settings.
Figures are computed from collected data and may differ slightly.
In a psychiatric outpatient sample, the PHQ-8 was as useful as the PHQ-9 for MDD screening.
The microbiota-gut-brain axis might provide novel targets for prevention and treatment of neuropsychiatric disorders. However, further studies are required to substantiate the clinical use of probiotics, prebiotics and FMT.
Depressive disorder is a common mental illness and remains a major cause of morbidity worldwide. The present study, a cross-sectional, nationwide, population-based survey assessed the prevalence of depression in the general population of Korea through a random sampling of the non-institutionalized population for the Korea National Health and Nutrition Examination Survey (KNHANES) VI. The Patient Health Questionnaire (PHQ)-9 was first introduced into the KNHANES to detect depression. The point pr
Our result supports reliability and validity with two-factor structure of PHQ-9 for measuring depression in the Korean nationally representative population. The Korean normative data on the PHQ-9 according to percentile rank can assist in interpreting and comparing scores with other populations.
Major depressive disorder (MDD) is a serious psychiatric illness that causes functional impairment in many people. While monoaminergic antidepressants have been used to effectively treat MDD, these antidepressants have limitations in that they have delayed onset of action and many patients remain treatment-resistant. Therefore, there is a need to develop antidepressants with a novel target, and researchers have directed their attention to the glutamatergic system. Ketamine, although developed as
The Korean version of the PTED Scale is a reliable and valid measurement of embitterment in Korean adults as an emotional reaction to a negative life event.
This study revealed an association between high plasma levels of CFH and geriatric depression, thereby suggesting the alternative pathway of the complement system contributing to the development of geriatric depression.
Here, we provide basic information about precision medicine and newly introduced concepts, such as the precision medicine ecosystem and big data processing, and omics technologies including pharmacogenomics, pharamacometabolomics, pharmacoproteomics, pharmacoepigenomics, connectomics and exposomics. The authors review the current state of omics in psychiatry and the future direction of psychopharmacology as it moves towards precision medicine. Expert commentary: Advances in precision medicine ha
Our results indicated no significant differences in the efficacy and tolerability of escitalopram, desvenlafaxine, and vortioxetine in this subtype of patients with anxious depression during the acute phase of treatment.
Buspirone augmentation did not demonstrate significant benefits in MDD patients; however, buspirone augmentation showed greater efficacy for the improvement of cognitive function in MDD patients without atypical features. Our study suggests that atypical features are an important factor for cognitive enhancement in buspirone augmentation treatment in patients with MDD.
Our preliminary findings have presented the effectiveness of aripiprazole augmentation for residual symptoms of partially remitted MDD patients in routine practice. This study assures subsequent well-controlled studies of the possibility of generalizing the above promising outcome in the future.
현대의학은 근거중심의학의 맥락에서 이해되고 있다. 진단 과 치료에 대한 임상적 의사결정은 의사의 습관, 관행, 개인 적 믿음보다 과학적 관찰과 실험을 통해 확립된 의학적 근거 에 기초해서 이루어져야 한다. 의학적 근거는 연구를 통해 얻 어지는데, 임상연구의 종류는 증례보고, 단면조사 연구, 환 자-대조군 연구, 메타분석 연구, 실험 연구 등을 포함하여 아 주 다양하다. 최근에는 생물학적 기초연구의 괄목할만한 발 전이 이루어지고, 인터넷 등을 통해 최신 정보를 실시간으로 얻는 것이 가능해진 환경하에서 수많은 연구가 진행되고 있 으며, 그 결과물인 연구 논문 또한 대량으로 발행되고 있다. 임상의사가 실제 환자의 진료 과정에서 임상 연구 결과를 이용한 의사결정을 하기 위해서는 참조하는 임상 연구 결과 에 대한 신뢰성이 전제되어야 한다. 연구 수행과정을 실제로 어떻게 하는지는 연구자의 윤리와 책임의식에서 비롯되는 것 이지만, 임상의사나 공공건강 정책 입안자 등 연구 논문의 독 자들은 출간된
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