Kyung Hee University · 生化学・遺伝学・分子生物学
Professor Cheon-Seok Park's research lab specializes in structural and biochemical enzymology, focusing on carbohydrate-active enzymes such as amylomaltase. The lab investigates the molecular mechanisms underlying enzyme function, particularly the conformational dynamics and catalytic activities of glycosyltransferases in thermophilic microorganisms. By combining X-ray crystallography with kinetic and mutagenesis studies, the lab aims to elucidate structure-function relationships that govern substrate specificity and catalytic efficiency. Their work contributes to the broader understanding of glycogen metabolism and has implications for industrial biotechnology and enzyme engineering.
Figures are computed from collected data and may differ slightly.
Amylomaltase, or 4-α-glucanotransferase (EC 2.4.1.25), is involved in glycogen and maltooligosaccharide metabolism in microorganisms, catalyzing both the hydrolysis and transfer of an α-1,4-oligosacchraride to other sugar molecules. In this study, we determined the crystal structure of amylomaltase from Thermus brockianus at a resolution of 2.3 Å and conducted a biochemical study to understand the detailed mechanism for its activity. Careful comparison with previous amylomaltase structures showe
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