早稲田大学 · 医学
林千祐教授の研究室では、神経疾患に関連する糖脂質修飾の分子機構に注目し、特にシアル酸を添加する酵素であるST8SIAファミリーの機能解明を進めています。特に脳内ストリオプセンに局在するST8SIA3の欠損がグルコース受容体の糖鎖修飾に与える影響を解析し、神経伝達系の機能的変化を解明しています。また、半導体デバイスの高効率化を目的としたGaN FETを用いた電力変換回路の開発も並行して実施しています。
Figures are computed from collected data and may differ slightly.
The protocol of this systematic review was registered on the International Prospective Register of Systematic Reviews (PROSPERO) on 2 December 2019 (registration number: CRD42019137341 ).
Sialic acids are typically added to the end of glycoconjugates by sialyltransferases. Among the six ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferases (ST8SIA) existing in adult brains, ST8SIA2 is a schizophrenia-associated gene. However, the in vivo substrates and physiological functions of most sialyltransferases are currently unknown. The ST8SIA3 is enriched in the striatum. Here, we showed that ablation of St8sia3 in mice (St8sia3-KO) led to fewer disialylated and trisialylated terminal gly
The findings have implications for allocating prevention and intervention resources targeted at high-risk groups in high incidence areas. Targets for area-based interventions might include tackling the causes and consequences of joblessness, better treatment of long-term illness and consideration of the accessibility of health services.
In this study, a buck power factor corrector (PFC) with gallium nitride field effect transistor (GaN FET) and integrated inductor is studied. An interleaved constant‐frequency clamped‐current control method is adopted to achieve high power factor, low input and output current ripples as well as high efficiency. Two inductors in the studied interleaved buck PFC are integrated to reduce the core loss. A 300 W/80 V laboratory prototype with 300 kHz switching frequency was built and tested under uni
Suicide rates and the prevalence of suicidal behaviors began to increase in Taiwanese youth in the 2010s. These increases may be associated with concurrent rises in parental divorce rates, Internet use and poor sleep. Further research is needed to examine the mechanisms underlying recent increases in youth suicide risk.
The study aimed to describe the prevalence of meeting moderate-to-vigorous-intensity physical activity (MVPA), muscle-strengthening (MS) activities, and television (TV) viewing guidelines, and their association with sociodemographic factors. Data from older adults aged 65 or above were sampled by age and sex to the population aged 65+ years for each area in Taiwan and collected through telephone interviews. The prevalence of meeting MVPA and MS activities, MVPA and MS activities guidelines, and
<b></b> <i>Background:</i> Few studies have investigated whether means accessibility is related to the spatial distribution of suicide. <i>Aims:</i> To examine the hypothesis that indicators of the accessibility to specific suicide methods were associated with method-specific suicide rates in Taipei City, Taiwan. <i>Method:</i> Smoothed standardized mortality ratios for method-specific suicide rates across 432 neighborhoods and their associations with means accessibility indicators were estimate
The investigated perceived environmental factors, which have previously been associated with facilitating active transportation, discourage sedentary modes of transport, such as motorized vehicles.
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