Seoul National University · 生化学・遺伝学・分子生物学
Professor Chong-Su Cho's research lab specializes in advanced biomaterials and nanomedicine, focusing on the development of smart polymeric and nanoparticulate systems for targeted drug and gene delivery. The lab investigates stimuli-responsive polymers—particularly pH-responsive and redox-sensitive materials—engineered to overcome biological barriers in intracellular and extracellular environments. A key research direction involves the application of natural polymers like chitosan and bioactive compounds such as EGCG in vaccine delivery and regenerative medicine. The lab also explores theranostic magnetic nanoparticles for imaging-guided therapy and the molecular mechanisms underlying cellular responses to bioactive agents.
Figures are computed from collected data and may differ slightly.
Our data demonstrate that EGCG decreased cell viability and inhibited differentiation of 3T3-L1 cells in a manner dependent on the duration of treatment. Also, we showed that inhibition of adipocyte differentiation by EGCG was associated with decreased glycerol-3-phosphate dehydrogenase (GPDH) activity accompanied by a strong inhibition of PPARgamma2-induced transcriptional activity. Furthermore, the inhibition of adipocyte differentiation by EGCG involved generation of ROS and activation of AMP
Today, nanotechnology plays a vital role in biomedical applications, especially for the diagnosis and treatment of various diseases. Among the many different types of fabricated nanoparticles, magnetic metal oxide nanoparticles stand out as unique and useful tools for biomedical applications, because of their imaging characteristics and therapeutic properties such as drug and gene carriers. Polymer-coated magnetic particles are currently of particular interest to investigators in the fields of n
Chitosan, a natural biodegradable polymer, is of great interest in biomedical research due to its excellent properties including bioavailability, nontoxicity, high charge density, and mucoadhesivity, which creates immense potential for various pharmaceutical applications. It has gelling properties when it interacts with counterions such as sulfates or polyphosphates and when it crosslinks with glutaraldehyde. This characteristic facilitates its usefulness in the coating or entrapment of biochemi
DNA vaccines offer a flexible and versatile platform to treat innumerable diseases due to the ease of manipulating vaccine targets simply by altering the gene sequences encoded in the plasmid DNA delivered. The DNA vaccines elicit potent humoral and cell-mediated responses and provide a promising method for treating rapidly mutating and evasive diseases such as cancer and human immunodeficiency viruses. Although this vaccine technology has been available for decades, there is no DNA vaccine that
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