名古屋大学 · 生化学・遺伝学・分子生物学
Mori教授の研究室では、神経発達障害や精神疾患の分子メカニズムを解明するため、細胞骨格のダイナミクスとRNA代謝の両面から分子機構を解析しています。特に、NDEL1やLIS1を介したマイクロチューブル組織と細胞分裂・ニューロン移動の制御、ならびにARHGAP10遺伝子の欠失変異が精神疾患に与える影響を遺伝子編集や画像解析を用いて解明しています。また、RNA-bindingタンパク質CUG-BP1のリガンド特異性の解明を通じて、筋ジストロフィーの病態メカニズムの解明にも貢献しています。
Figures are computed from collected data and may differ slightly.
NDEL1 is a binding partner of LIS1 that participates in the regulation of cytoplasmic dynein function and microtubule organization during mitotic cell division and neuronal migration. NDEL1 preferentially localizes to the centrosome and is a likely target for cell cycle-activated kinases, including CDK1. In particular, NDEL1 phosphorylation by CDK1 facilitates katanin p60 recruitment to the centrosome and triggers microtubule remodeling. Here, we show that Aurora-A phosphorylates NDEL1 at Ser251
Schizophrenia (SCZ) is known to be a heritable disorder; however, its multifactorial nature has significantly hampered attempts to establish its pathogenesis. Therefore, in this study, we performed genome-wide copy-number variation (CNV) analysis of 2940 patients with SCZ and 2402 control subjects and identified a statistically significant association between SCZ and exonic CNVs in the ARHGAP10 gene. ARHGAP10 encodes a member of the RhoGAP superfamily of proteins that is involved in small GTPase
CUG-binding protein 1 (CUG-BP1) is a member of the CUG-BP1 and ETR-3-like factors (CELF) family of RNA-binding proteins, and is involved in myotonic dystrophy type 1 (DM1). Several mRNA targets of CUG-BP1 have been identified, including the insulin receptor, muscle chloride channel, and cardiac troponin T. On the other hand, CUG-BP1 has only a weak affinity for CUG repeats. We conducted quantitative-binding assays to assess CUG-BP1 affinities for several repeat RNAs by surface plasmon resonance
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