Sungkyunkwan University · 医学
Professor Dongryul Oh's research lab specializes in radiation oncology and cancer survivorship, focusing on the long-term complications of radiotherapy, particularly radiation-induced insufficiency fractures and radiation proctitis. The lab investigates dosimetric predictors, sarcopenia, and prognostic factors in patients with gynecological and pelvic malignancies, aiming to improve treatment outcomes and quality of life. Their work integrates medical imaging, radiation biology, and clinical oncology to refine radiotherapy strategies and identify high-risk patients.
Figures are computed from collected data and may differ slightly.
Insufficiency fracture occurs when normal or physiological stress applied to weakened bone with demineralization and decreased elastic resistance. Recently, many studies reported the development of IF after radiation therapy (RT) in gynecological cancer, prostate cancer, anal cancer and rectal cancer. The RT-induced insufficiency fracture is a common complication during the follow-up using modern imaging studies. The clinical suspicion and knowledge the characteristic imaging patterns of insuffi
Excessive muscle loss rather than pre- and post-RT sarcopenia was a significant prognostic factor for OS and RFS, and it was also related to nutritional and inflammatory markers.
Dosimetric parameters were valuable in predicting the development of RP.
Lymph node metastasis was a poor prognostic factor and adjuvant RT may be useful in patients with microscopic residual tumor. However, because there were high loco-regional recurrences, additional study is needed to determine more effective RT such as increased RT dose or use of radiosensitizers.
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