Seoul National University · 医学
Professor Euitae Kim's research lab specializes in molecular imaging and pharmacological neuroimaging, focusing on the neurobiological mechanisms underlying schizophrenia and other CNS disorders. The lab develops and validates advanced PET imaging techniques—such as partial volume correction methods like SFS-RR—to improve the accuracy of measuring dopamine synthesis capacity and receptor occupancy. By integrating pharmacokinetic-pharmacodynamic (PK-PD) modeling with molecular imaging, the lab investigates how antipsychotic dosing and treatment timing influence brain function and clinical outcomes, particularly in early-stage schizophrenia. The research emphasizes translational applications, aiming to support early diagnosis, personalized treatment, and improved therapeutic strategies.
Figures are computed from collected data and may differ slightly.
Positron emission tomography (PET) studies of dopamine receptor occupancy can be used to assess dosing of antipsychotics. Typically, studies of antipsychotics have applied pharmacodynamic (PD) modeling alone to characterize the relationship between antipsychotic dose and its effect on the brain. However, a limitation of this approach is that it does not account for the discrepancy between the time courses of plasma concentration and receptor occupancy by antipsychotics. Combined pharmacokinetic-
Starting paliperidone LAI significantly improved clinical and functional outcomes in patients with schizophrenia, especially those with shorter duration of illness. These findings suggest that LAI antipsychotic administration may be considered in early-stage schizophrenia for improved outcomes.
Molecular imaging techniques have a number of advantages for research into the pathophysiology and treatment of central nervous system (CNS) disorders. Firstly, they provide a noninvasive means of characterizing physiological processes in the living brain, enabling molecular alterations to be linked to clinical changes. Secondly, the pathophysiological target in a given CNS disorder can be measured in animal models and in experimental human models in the same way, which enables translational res
We validated the use of a novel image-based method for partial volume correction (PVC), structural-functional synergistic resolution recovery (SFS-RR) for the accurate quantification of dopamine synthesis capacity measured using [(18)F]DOPA positron emission tomography. The bias and reliability of SFS-RR were compared with the geometric transfer matrix (GTM) method. Both methodologies were applied to the parametric maps of [(18)F]DOPA utilization rates (ki(cer)). Validation was first performed b
In a naturalistic setting, the different pattern of exposure to antipsychotics between the converter and non-converter groups calls attention to the effects of antipsychotics on conversion to psychosis.
The relationship between striatal dopamine synthesis capacity and frontostriatal FC is different between responders to first-line treatment and clozapine treatment in schizophrenia, indicating that a different pathophysiology could underlie schizophrenia in patients who respond to first-line treatments relative to those who do not.
노숙인은 자신의 삶을 변화시키기 위한 장기적이고 체계적인 교육기회를 얻기가 어렵다. 이런 점에서 평생교육의 장에서 진행되고 있는 노숙인 대상 인문교양교육은 응급 구호와 물질적 차원의 일시적 지원과 달리 자존감 회복과 자기성찰을 통해 자립할 수 있는 근원적인 힘을 확보하는 통로라 할 수 있다. 이 연구에서는 노숙인이 인간으로서의 존엄성과 가치를 회복하고 장기적으로 삶의 방향을 재설정하는 계기로서 인문교양교육이 어떻게 작동하는지를 살펴보기 위해 대한성공회 노숙인다시서기지원센터가 운영하고 있는 <성프란시스대학 인문학과정>을 사례로 삼았다. 이 사례를 통해 노숙인을 성인 학습자로 간주하는 프로그램의 구조와 특성을 제시하고, 실제 프로그램 참여 노숙인의 학습경험이 어떤 양상으로 전개되었는지를 제시했다. 노숙인은 참여과정에서 ‘경계'에 서있는 학습자로서 경제적 어려움과 현실과의 괴리감 등으로 내적 갈등을 겪기도 했지만, 대화와 토론, 글쓰기 경험을 통해 자신의 생애경험과 맞물려 인문학적 질문들
The aim of the present study was to evaluate the effects of polymorphisms in dopamine D2 receptor (DRD2) and cytochrome P450 (CYP) 2D6 genes on delta EEG power response to aripiprazole in healthy male volunteers. Seventeen volunteers were recruited according to the DRD2 Taq1A genotype, and separated into the following groups: homozygous wild-type (A2/A2, n = 7), heterozygous (A2/A1, n = 5) and homozygous variant-type (A1/A1, n = 5) groups. After enrollment in this study, they were genotyped for
This suggests that DRD2 Taq1A polymorphism status may be associated with the clinical response to aripiprazole.
These findings indicate that the earlier the age of onset of OCD, the less serotonergic pathology there is and that this difference remains even after long-term serotonin reuptake inhibitor treatment. Clinically, it might suggest that nonserotonergic treatments would be a better option for EOCD patients.
UKRI Future Leaders Fellowship, British Medical Association Margaret Temple Award for Schizophrenia Research, and the National Research Foundation of Korea-Korea Government.
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