Yonsei University · 医学
Professor Eunhyang Park's research lab specializes in translational cancer research, focusing on identifying and validating biomarkers for precision oncology in lung and ovarian cancers. The lab investigates cancer stem cell markers, tumor suppressor gene mutations (e.g., TP53), and signaling pathways (e.g., IGF1R, PARP) to improve prognostic prediction and therapeutic selection. A key emphasis is on integrating immunohistochemistry with next-generation sequencing to refine molecular diagnostics and guide targeted therapy in Asian populations, particularly Koreans.
Figures are computed from collected data and may differ slightly.
Cancer stem cells (CSCs) are a small subset of tumor cells that exhibit stem cell-like properties and contribute in treatment failure. To clarify the expression and prognostic significance of several CSC markers in non-small cell lung cancer, we retrospectively analyzed 368 patients with adenocarcinoma (n = 226) or squamous cell carcinoma (n = 142). We correlated the expression of six CSC markers - CD133, CD44, aldehyde dehydrogenase 1 (ALDH1), sex determining region Y-box 2 (SOX2), octamer bind
High-grade serous carcinoma (HGSCa) of the ovary is featured by <i>TP53</i> gene mutation. Missense or nonsense mutation types accompany most cases of HGSCa that correlate well with immunohistochemical (IHC) staining results-an all (missense) or none (nonsense) pattern. However, some IHCs produce subclonal or mosaic patterns from which TP53 mutation types, including the wild type of the gene, cannot be clearly deduced. We analyzed a total of 236 cases of ovarian HGSCa and tumors of other histolo
Umbilical discharge in infancy is a common pediatric problem and usually attributed to infection or an umbilical granuloma. However, it is important to investigate if such discharge is due to an underlying congenital abnormality such as umbilical hernia ulceration, urachal remnant, or omphalomesenteric duct remnant, because corrective surgical intervention may then be required. Omphalomesenteric duct remnant can cause umbilical discharge generally through patency between the gut and umbilicus. H
Lung ADC and SqCC showed distinct IGF1R expression profiles that demonstrated prognostic significance. High membranous IGF1R expression was predictive of poor PFS in EGFR-mutant lung ADC, while it was predictive of better PFS in SqCC. These findings will help improve study design for subsequent investigations and select patients for future anti-IGF1R therapy.
Even though the conventional and NGS methods were concordant in the majority of cases, NGS testing still revealed a considerable number of additional EGFR, ALK, and ROS1 alterations, as well as other targetable alterations, in Korean advanced-stage lung cancer patients. Given the high frequency of EGFR and other targetable mutations identified in the present study, NGS testing is highly recommended in the diagnosis of Korean lung cancer patients.
RAD51 is a potential functional IHC biomarker of <i>de novo</i> and acquired PARPi resistance in <i>BRCA</i>-mutated ovarian cancer and can be used to fine-tune ovarian cancer treatment.
Combined tumor epithelial and stromal histopathology with keratin 81 expression is suggested to be useful for predicting prognosis of PDAC.
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