Sungkyunkwan University · 医学
Professor Eun-Suk Kang's research lab focuses on immunology and cancer biology, with a particular emphasis on tumor microenvironment regulation, T cell biology, and mitochondrial protein transport in cancer progression. The lab investigates the role of immune cell subsets—such as regulatory T cells and myeloid-derived suppressor cells—in gastric and ovarian cancers, aiming to identify prognostic biomarkers and therapeutic targets. Additionally, the lab explores mechanisms of immune tolerance and protein trafficking in mitochondria, especially the TOM40 complex, linking cellular metabolism to cancer pathogenesis. Their work also extends to clinical applications, including stem cell mobilization for transplantation and diagnostic biomarkers in autoimmune neurological disorders.
Figures are computed from collected data and may differ slightly.
The prognostic effects of tumor infiltrating lymphocytes (TILs), especially regulatory T cells (Tregs) and myeloid derived suppressing cells (MDSCs) are inconclusive in gastric cancers. We investigated the frequencies of TILs including CD8+ T cells, CD45+CD4+CD25± FOXP3+ Tregs, CD45+CD11b+ CD14+ HLA-DR- MDSCs in 28 gastric cancer tissues by using multicolor flow cytometry. In gastric cancer tissue, the percentage of Tregs among the CD4+ T cell subset was substantially increased compared to that
Transgenic mice expressing an alloreactive TCR specific for the MHC class I Ag K(b) were used to examine the mechanism by which genetic engineering of bone marrow induces T cell tolerance. Reconstitution of lethally irradiated mice with bone marrow infected with retroviruses carrying the MHC class I gene H-2K(b) resulted in lifelong expression of K(b) on bone marrow-derived cells. While CD8 T cells expressing the transgenic TCR developed in control mice reconstituted with mock-transduced bone ma
Detection of AQP4 antibodies by CIIFA provides sensitive and highly specific diagnostic information for NMO and high-risk NMO patients, which can be used to differentiate these conditions from other demyelinating CNS diseases.
TOM40 is a channel-forming subunit of translocase, which is essential for the movement of proteins into the mitochondria. We found that TOM40 was highly expressed in epithelial ovarian cancer (EOC) cells at both the transcriptional and translational levels; its expression increased significantly during the transformation from normal ovarian epithelial cells to EOC (<i>p</i> < 0.001), and TOM40 expression negatively correlated with disease-free survival (Hazard ratio = 1.79, 95% Confidence inerva
In conventional G-CSF-based mobilization, early PBSC collection after G-CSF administration might enhance CD34+ cell yield. A combination of a new mobilizing agent, plerixafor, would be helpful to harvest sufficient number of CD34+ cells for successful transplantation outcome while reducing the effort of collection procedures in poor mobilizers.
Open papers in the app to read, cite, and organize with AI.
