慶應義塾大学 · 神経科学
神戸大学の金子史成教授の研究室は、脳の運動制御と神経可塑性に焦点を当てた神経科学研究を展開しています。視覚刺激を用いた運動錯覚(キネスティック錯覚)が運動皮質の可塑性に与える影響をfMRIやTMSを用いて解明しており、特に脳卒中の慢性期における上肢機能回復に有効な非侵襲的神経調節法の開発を目的としています。運動想起(MI)や経頭蓋静脈刺激(tDCS)と組み合わせた治療的アプローチの神経メカニズムの解明が、今後のリハビリテーション医療の革新をめざしています。
Figures are computed from collected data and may differ slightly.
It is well known that kinesthetic illusions can be induced by stimulation of several sensory systems (proprioception, touch, vision…). In this study we investigated the cerebral network underlying a kinesthetic illusion induced by visual stimulation by using functional magnetic resonance imaging (fMRI) in humans. Participants were instructed to keep their hand still while watching the video of their own moving hand (Self Hand) or that of someone else's moving hand (Other Hand). In the Self Hand
Prolonged electromechanical delay in twitch response may be due to peripheral physiological disruptions (eg, stiffness of the series elastic component, changes of peripheral muscle fiber-type composition, or a decrease in function of the excitation-contraction coupling process). A prolonged electromechanical delay in twitch response can also explain the prolonged electromechanical delay observed for MVC. These findings suggest that prolonged total reaction time in MVC, when secondary to a visual
The combination of voluntary effort and functional electrical stimulation (ES) appears to have a greater potential to induce plasticity in the motor cortex than either electrical stimulation or voluntary training alone. However, it is not clear whether the motor commands from the central nervous system, the afferent input from peripheral organs, or both, are indispensable to induce the facilitative effects on cortical excitability. To clarify whether voluntary motor commands enhance corticospina
Barring a few studies, there are not enough established treatments to improve upper limb motor function in patients with severe impairments due to chronic stroke. This study aimed to clarify the effect of the kinesthetic perceptional illusion induced by visual stimulation (KINVIS) on upper limb motor function and the relationship between motor function and resting-state brain networks. Eleven patients with severe paralysis of upper limb motor function in the chronic phase (seven men and four wom
A kinesthetic illusion induces a feeling as if an individual’s own body is moving during sensory input, even though the body is actually in a resting state. In a previous study, we reported that a visually induced kinesthetic illusion (KiNVIS) increases corticospinal tract excitability that is associated with activity of the motor-association regions. The present study explored the acute effect of KiNVIS on motor function in five patients who had experienced stroke, as a preliminary study. Five
Our results suggest that tDCSa + KIMI has a greater therapeutic potential than tDCS alone for inducing higher excitability of the corticospinal tract. The observed effects may be related to sustained potentiation of resultant cerebral activity during combined KI, MI, and tDCSa.
This meta-analysis demonstrated that RAGT therapy in combination with NIBS was effective in patients with stroke and SCI. However, a greater improvement in lower limb function and activities were not observed using RAGT with tDCS compared to sham stimulation.
In patients with chronic stroke who were unable to extend their paretic fingers for a prolonged period of time, the application of KINVIS, which evokes kinesthetic perception, improved their ability to induce motor imagery. Our findings suggest that although KINVIS is a passive intervention, its short-term application can induce changes related to the motor output system.
<b>Aims:</b> Therapy with kinesthetic illusion of segmental body part induced by visual stimulation (KINVIS) may allow the treatment of severe upper limb motor deficits in post-stroke patients. Herein, we investigated: (1) whether the effects of KINVIS therapy with therapeutic exercise (TherEx) on motor functions were induced through improved spasticity, (2) the relationship between resting-state functional connectivity (rs-FC) and motor functions before therapy, and (3) the baseline characteris
The authors investigated whether working memory training improves motor-motor dual-task performance consisted of upper and lower limb tasks. The upper limb task was a simple reaction task and the lower limb task was an isometric knee extension task. 45 participants (age = 21.8 ± 1.6 years) were classified into a working memory training group (WM-TRG), dual-task training group, or control group. The training duration was 2 weeks (15 min, 4 times/week). Our results indicated that working memory ca
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