Gang-Jee Ko

Although high-protein diets continue to be popular for weight loss and type 2 diabetes, evidence suggests that worsening renal function may occur in individuals with-and perhaps without-impaired kidney function. High dietary protein intake can cause intraglomerular hypertension, which may result in kidney hyperfiltration, glomerular injury, and proteinuria. It is possible that long-term high protein intake may lead to <i>de novo</i> CKD. The quality of dietary protein may also play a role in kid

These results suggest that macrophages play an important role in mediating persistent inflammation and fibrosis after ischaemia/reperfusion leading to a development of chronic kidney disease. Strategies targeting macrophage infiltration or activation can be useful in the prevention of development of chronic kidney disease following ischaemic injury.

These data suggest that pioglitazone not only improves insulin resistance, glycaemic control and lipid profile, but also ameliorates renal injury through an anti-inflammatory mechanism in type 2 diabetic rats.

Contrast-induced nephropathy (CIN) is an impairment of renal function that occurs after the administration of an iodinated contrast medium (CM). Kidney dysfunction in CIN is considered transient and reversible in most cases. However, it is the third most common cause of hospital-acquired acute kidney injury and is associated with increased morbidity and mortality, especially in high-risk patients. Diagnostic and interventional procedures that require intravascular CM are being used with increasi

High dietary protein intake may lead to increased intraglomerular pressure and glomerular hyperfiltration, which in the long-term can lead to de novo or aggravating preexisting chronic kidney disease (CKD). Hence, a low protein diet (LPD, 0.6 to 0.8 g/kg/day) is recommended for the management of CKD. There are evidences that dietary protein restriction mitigate progression of CKD and retard the initiation of dialysis or facilitate incremental dialysis. LPD is also helpful to control metabolic de

Few layer graphene (FLG) samples contacted were irradiated with protons at an energy of 5 MeV and doses up to . The electrical properties of ungated FLG sheets contacted by Pd/Au in a source (S)–drain (D) configuration, including , , and the hole mobility, were compared before and after proton irradiation. After irradiation, it is observed that the ambipolar conduction of the FLG sheets was changed to a p-type conduction. The field-effect mobility of the hole carriers and the resistance in the g

Deteriorating kidney function is frequently observed in the elderly population, as well as vulnerability to acute kidney failure, such as ischemic/reperfusion injury (IRI), and inadequate recovery from IRI is one of the mechanisms of kidney dysfunction in the elderly. The potential mediators in the progression of kidney dysfunction in the aging kidney have not yet been clearly revealed. In this study, we investigated the role of nuclear factor erythroid 2-related factor 2 (NRF2), which is an ess

The rapid growth of the elderly population is making the need for extensive and advanced information about age-related organ dysfunction a crucial research area. The kidney is one of the organs most affected by aging. Aged kidneys undergo functional decline, characterized by a reduction in kidney size, decreased glomerular filtration rate, alterations in renal blood flow, and increased inflammation and fibrosis. This review offers a foundation for understanding the functional and molecular mecha

The role of statins in chronic kidney disease (CKD) has been extensively evaluated, but it remains controversial in specific population such as dialysis-dependent CKD. This study examined the effect of statins on mortality in CKD patients using two large databases. In data from the Observational Medical Outcomes Partnership Common Data Model (OMOP-CDM) from two hospitals, CKD was defined as an estimated glomerular filtration rate < 60 mL/min/m²; we compared survival between patients w

<b>Background:</b> Neprilysin inhibition has demonstrated impressive benefits in heart failure treatment, and is the current focus of interest in cardiovascular (CV) and kidney diseases. However, the role of circulating neprilysin as a biomarker for CV events is unclear in hemodialysis (HD) patients. <b>Methods:</b> A total of 439 HD patients from the K-cohort were enrolled from June 2016 to April 2019. The plasma neprilysin level and echocardiographic findings at baseline were examined. The pat

It is suggested that DNA methylation on specific genes is associated with the development of CKD and the deterioration of kidney function.

Hemodialysis was implicated in various medical disputes, and CVC-related complications were the most common and serious adverse events. Clinicians' awareness of the incidence and severity of possible complications of hemodialysis procedures should be increased.

목적 : 혈액투석을 시행하는 만성 신부전 환자에서 만성 염증상태가 지속되는 것이 영양 결핍과 심혈관계 합병증 증가와 관련되어 있다는 연구가 이루어지고 있다. IL-10은 항염증 사이토카인 중 중추적 역할을 담당하는 것으로 유전자형에 따라 혈중 농도의 변화가 보고된 바 있다. 이에 본 연구에서는 만성 신부전 환자에서의 IL-10 혈중농도를 정상군과 비교하고 유전자형에 따른 농도변화와 심혈관계 질환 위험인자와의 상관성을 분석하였다. 방법 : 정상군 98명,

배경: 저산소 손상에 의한 신세뇨관 상피세포의 괴사 및 아포프토시스는 이미 잘 알려져 있으며, 급성 허혈성 신부전의 중요한 병태생리으로 생각되나, 이를 매개하는 세포내 기전에 대해서는 잘 알려져 있지 않다. Mitogen activated protein kinase (MAPK)는 다양한 종류의 외부 자극에 대한 세포 반응을 매개 또는 조절하는 신호전달체계로서, 본 연구에서는 저산소 손상시 발생하는 신세뇨관 상피세포의 아포프토시스와 MAPK와의 연관성에 대하여 연구하고자 하였다. 방법: 사람의 근위 세뇨관 상피세포를 우태아 혈청이 포함되지 않은 기본 배양액을 이용하여 저산소 배양기 (O2<1%)에 24시간 동안 배양하였다. 아포프토시스는 Hoechst 33342 염색과 세포주기 분석, caspase의 활성화로 관찰하였고, MAPK의 활성화는 western blot을 통해 분석하였으며, MAPK에 대한 억제제를 사용하여 저산소 손상에 의한 신세뇨관 상피세포의 아포프토시스를 매개하는 신호