九州大学 · 医学
モトムラ教授の研究室では、大腿骨頭壊死（ONFH）の発症メカニズムと治療戦略の解明を目的として、実験的・臨床的・計算的アプローチを統合した研究を推進しています。特に、ステロイド誘因性ONの予防に効果を示す薬剤の併用や、壊死巣周囲の骨の力学的変化、ならびに患者個別に再構築した有限要素モデルを用いた応力分布解析が特徴です。微小CTを用いた組織レベルの評価と画像診断（MRI・CT）の統合的解析により、早期段階の変化を高精度に捉える研究が進められています。
Figures are computed from collected data and may differ slightly.
This study experimentally confirmed that the combined use of an anticoagulant and a lipid-lowering agent helps prevent steroid-induced ON in rabbits.
In order to investigate the mechanisms of collapse in osteonecrosis of the femoral head, we examined which part of the femoral head was the key point of a collapse and whether a collapsed region was associated with the size of the necrotic lesion. Using 30 consecutive surgically removed femoral heads we retrospectively analysed whole serial cut sections, specimen photographs, specimen radiographs and histological sections. In all of the femoral heads, collapse consistently involved a fracture at
Stress distribution remains unclear in early-stage osteonecrosis of the femoral head (ONFH). To clarify this issue, we generated patient-specific finite element models (FEMs) from 51 patients with ONFH. Patients' hips were classified into three groups: ONFH without a sclerotic boundary (Stage 1, n = 6), ONFH with a sclerotic boundary (Stage 2, n = 10), and ONFH with both a sclerotic boundary and <2 mm collapse (Stage 3, n = 35). Four hips without ONFH were used as controls. Stress distribution i
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