北海道大学 · 医学
Asahina教授の研究室は、非小細胞肺癌をはじめとする呼吸器腫瘍学分野に焦点を当て、特にEGFR変異を有する肺がんに対する標的療法や免疫チェックポイント阻害剤の有効性・安全性を臨床的に検証しています。高齢者における免疫療法の最適な選択肢や、画像ガイドド生検技術の改良についても革新的な試みを行っており、患者に適した個別化医療の実現を目指しています。
Figures are computed from collected data and may differ slightly.
Gefitinib represents a useful therapeutic option for selected previous gefitinib responders.
In this study, ICI-chemotherapy combination treatment did not improve survival and increased the incidence of grade 3 and higher immune-related adverse events compared with ICI alone in patients 75 years and older. Based on these results, ICI alone may be recommended for older adult patients with PD-L1-positive NSCLC.
ICI is also effective in elderly NSCLC patients, and treatment discontinuation due to irAEs may be a good prognostic marker.
Linifanib was well tolerated with promising preliminary clinical activity in Japanese patients. Later-phase global studies examining linifanib efficacy will include Japanese patients.
Our attempt to perform TBB under real-time EBUS guidance for PPLs was successful in 4 of 6 patients. There were some technical limitations using flexible bronchoscopy with 2 working channels. Improvement of instruments will be necessary for future trials of TBB under real-time EBUS guidance.
13014 Background: Activating mutations in exon 18–21 of the epidermal growth factor receptor (EGFR) gene have been reported to be a predictor of response to gefitinib. We conducted a phase II study to evaluate the efficacy and safety of gefitinib as a first-line therapy for advanced non-small cell lung cancers (NSCLCs) with EGFR gene mutations. Methods: The primary endpoint was response rate (RR). Eligiblity criteria were stage IIIB or IV chemotherapy naive NSCLC, ECOG PS of 0–2, adequate organ
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