Seoul National University · 医学
Professor Hak Jae Kim's research lab specializes in thoracic oncology, with a primary focus on the diagnosis, treatment, and prognosis of patients with soft tissue sarcoma (STS), particularly those with primary sarcoma of the lung. The lab investigates the role of adjuvant radiotherapy in improving local control and survival outcomes, and identifies key pathological predictors—such as high mitotic activity—for disease progression. Their work emphasizes optimizing treatment strategies through integrated multimodal approaches and personalized risk assessment.
Figures are computed from collected data and may differ slightly.
The lung and primary site were frequent sites of failure in patients treated with definitive surgery for SS. Adjuvant RT improved LRFS and PFS. Frequent mitotic figures (≥10 mitoses per 10 HPF) were the worst prognostic factor for these patients.
RTOG grade 3 late rectal and bladder morbidity developed in respectively 7.4% and 1.9% of the patients. The significant risk factors for late rectal and bladder morbidity were old age and biologically effective doses at the bladder reference point, respectively.
This study reports the pharmacokinetics and tissue distribution of a novel histone deacetylase and DNA methyltransferase inhibitor, psammaplin A (PsA), in mice. PsA concentrations were determined by a validated LC-MS/MS assay method (LLOQ 2 ng/mL). Following intravenous injection at a dose of 10 mg/kg in mice, PsA was rapidly eliminated, with the average half-life (t1/2, λn) of 9.9 ± 1.4 min and the systemic clearance (CLs) of 925.1 ± 570.1 mL/min. The in vitro stability of PsA was determined in
유럽에서는 냉전기간 동안 상대적인 평화를 유지했지만 동아시아에서는 한국전쟁과 대만해협분쟁 베트남전 등의 열전과 군사적 갈등이 빈번하게 발생했다. 이 글은 이렇게 유럽과 동아시아에서 지역냉전이 다르게 전개된 원인과 역사적 발전경로를 추적하기 위해 역사제도주의의 사전조건, 균열구조, 결정적 국면, 초기 포섭양식, 유산의 지속과 차별적 대응이라는 개념적 분석틀을 적용했다. 분석결과 먼저 유럽과 동아시아는 냉전의 사전조건부터 달랐다. 유럽에선 오랜 기간 국민국가 체제가 자리잡은 상태에서 독일문제를 다자주의적으로 처리하려 했지만, 동아시아는 식민지배에서 벗어나 새로운 독립국가를 수립하는 것이 가장 큰 당면 과제였다. 둘째, 유럽과 동아시아는 냉전 균열구조의 형성과 결정적 국면의 양상이 달랐다. 유럽의 냉전과 분단은 1949년부터 1955년경까지 느리고 약하게 진행되었지만, 동아시아에서는 1948년에 분단정부가 수립되고 1950년엔 지역차원의 전면전인 한국전쟁이 발발했다. 유럽은 미소 냉전 균
The use of POEFRT resulted in an excellent loco-regional control rate. The addition of chemotherapy may improve outcome in patients who have received POEFRT, but with higher manageable toxicity.
Objective: To evaluate treatment outcomes and prognostic factors in uterine cervical cancer patients treated with postoperative extended field radiation therapy (POEFRT) with or without chemotherapy. Methods: Between 1983 and 2006, 35 patients with a pathologically confirmed positive para-aortic node (PAN) or common iliac node (CIN) who underwent a radical hysterectomy with bilateral pelvic lymph node dissection and PAN dissection received POEFRT with (N=23) or without (N=12) chemotherapy. Progn
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