大阪大学 · 神経科学
Hideo Matsuzaki教授の研究室は、神経保護作用を示す成長因子の神経細胞におけるシグナル伝達機構を解明する研究を行っています。特に、血管内皮増殖因子（VEGF）やインスリン様成長因子-1（IGF-1）がPI3K/AktおよびMEK/ERK経路を介してニューロンの死を防ぐメカニズムに注目しており、神経変性疾患や神経障害の治療への応用を視野に入れています。また、自閉症スペクトラム症候群（ASD）における感情認識の障害の神経基盤についても、fMRIを用いた脳機能画像解析を通じて解明を進めています。
Figures are computed from collected data and may differ slightly.
ABSTRACT Vascular endothelial growth factor (VEGF) is known as a selective endothelial cell mitogen that promotes angiogenesis and increases blood vessel formation in vivo. Here we report that VEGF has protective effects on primary hippocampal neurons against glutamate toxicity by acting on phosphatidylinositol 3‐kinase (PI3‐K)/Akt pathways and mitogen‐activated protein kinase kinase (MEK)/extracellular signal‐regulated kinase (ERK) pathways, operating independently of one another. Decrease in t
Emerging data indicate that growth factors such as insulin-like growth factor-1 (IGF-1) prevent neuronal death due to nitric oxide (NO) toxicity. On the other hand, growth factors can promote cell survival by acting on phosphatidylinositol 3-kinase (PI3-kinase) and its downstream target, serine-threonine kinase Akt, in various types of cells. Here, we examined the mechanism by which IGF-1 inhibits neuronal apoptosis induced by NO in primary hippocampal neurons. IGF-1 was capable of preventing ap
Individuals with autism spectrum disorders (ASD) tend to make inadequate social judgments, particularly when the nonverbal and verbal emotional expressions of other people are incongruent. Although previous behavioral studies have suggested that ASD individuals have difficulty in using nonverbal cues when presented with incongruent verbal-nonverbal information, the neural mechanisms underlying this symptom of ASD remain unclear. In the present functional magnetic resonance imaging study, we comp
This study was supported mainly by MEXT, Japan.
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