慶應義塾大学 · 医学
Kawakubo教授の研究室は、食道がんの治療戦略と発がんメカニズムの解明を柱としています。特に、術式の最適化（例：3-field lymphadenectomyやミニ invasive による食道切除）と、がん化の初期段階における分子的イベント（p53、cyclin D1など）の解析を通じて、がんの発生メカニズムと治療成績の向上に貢献しています。臨床的意義に裏付けられた分子標榜と手術戦略の統合的アプローチが特徴です。
Figures are computed from collected data and may differ slightly.
Extended TMIE including thoracic duct resection increased the number of lymph nodes retrieved and was associated with improved survival in patients with cT1 N0 oesophageal squamous cell carcinoma.
Many molecular alterations occur in esophageal carcinogenesis; however, little is known about the molecular genetic events responsible for the development of carcinoma. We investigated the expression of ki67, p53, cyclin D1 and pRB in 105 biopsy specimens using immunohistochemistry from iodine unstained lesions as indicators of carcinogenesis of the esophagus. Also, the genetic alternation of esophageal dysplasia from patients with accompanying esophageal squamous cell carcinoma (ESCC) was exami
Esophageal cancer has one of the highest malignant potentials of any type of tumor. The 3-field lymph node dissection is the standard procedure in Japan for surgically curable esophageal cancer in the middle or upper thoracic esophagus. Minimally invasive esophagectomy is being increasingly performed in many countries, and several studies report its feasibility and curability; further, the magnifying effect of the thoracoscope is another distinct advantage. However, few studies have reported tha
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