名古屋大学 · 医学
Watanabe教授の研究室は、神経変性疾患、特に多発性発達性萎縮（MSA）やレビー小体病変（DLB）を対象とした神経画像診断と生体アッセイの研究を専門としています。特に、MRSやMIBGシンチグラフィーを用いた神経変性の早期診断や病態解明に貢献しており、臨床的・画像的所見の整合性を高める研究が進んでいます。
Figures are computed from collected data and may differ slightly.
We investigated the disease progression and survival in 230 Japanese patients with multiple system atrophy (MSA; 131 men, 99 women; 208 probable MSA, 22 definite; mean age at onset, 55.4 years). Cerebellar dysfunction (multiple system atrophy-cerebellar; MSA-C) predominated in 155 patients, and parkinsonism (multiple system atrophy-parkinsonian; MSA-P) in 75. The median time from initial symptom to combined motor and autonomic dysfunction was 2 years (range 1-10). Median intervals from onset to
Cardiac (123)I-meta-iodobenzylguanidine (MIBG) uptake was measured in 11 patients with dementia with Lewy bodies (DLB), 10 patients with Alzheimer's disease (AD), and 10 age matched control subjects. The severity of cognitive impairment and duration of symptoms in patients with DLB matched that in the patients with AD. The heart/mediastinum (H/M) ratio of MIBG uptake in the patients with AD was indistinguishable from that in the control subjects. However, the H/M ratio in all patients with DLB w
(1)H-MRS showed widespread neuronal and axonal involvement in MSA. The NAA/Cr reduction in the pontine base proved highly informative in the early diagnosis of MSA prior to MRI changes and even before any clinical manifestation of symptoms.
VH in PD can occur due to distinctive neuroanatomical involvement.
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