東京大学 · 生化学・遺伝学・分子生物学
Aburatani教授の研究室では、酸化的損傷によって発生するDNA塩基傷害、特に8-ヒドロキシグアニン（8-OH-G）の修復機構に注目し、その修復に関与する酵素「hMMH」の機能解明を進めています。特に、酸化的ストレスが引き起こす遺伝子変異やがん発症のメカニズムの解明を目指しており、遺伝子修復系の分子機構を解析しています。
Figures are computed from collected data and may differ slightly.
8-Hydroxyguanine (8-OH-G) is one of the major DNA oxidation products implicated in mutagenesis induced by oxygen radical-forming agents, including ionizing radiation. It is also believed to be involved in spontaneous mutation induced by metabolically produced oxygen radicals. A mammalian homologue of 8-OH-G glycosylase/apurinic, apyrimidinic lyase (mutM homologue, MMH) has been identified in the EST database (for expressed sequence tags) through a homology search with yeast OGG1 protein. The hum
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