京都大学 · 医学
藤本博之教授の研究室は、酸化物超伝導体の機械的特性と超伝導特性の向上を柱としており、特にMPMG法で作製されたYBCO材料における微粒子の強化メカニズムや、結晶面に起因する破壊靭性の異方性を解明しています。また、リチウムイオン二次電池の炭素負極におけるリチウムインターカレーション挙動を、操作的X線回折を用いて三次元構造の詳細にわたって解析し、反応機構の解明を進めています。さらに、糖尿病の非画像的β細胞質量評価を目的としたPETプローブの開発や、siRNAを用いた遺伝子スクリーニング技術の構築にも取り組んでいます。
Figures are computed from collected data and may differ slightly.
The fracture toughness of melt-powder-melt-growth(MPMG)-processed YBaCuO samples was measured and the beneficial effect of the dispersed 211 particles in the 123 superconducting phase on toughening the material was confirmed. Preferred fracture planes were (100), (010) and (001) planes, and the fracture toughness of the (001) plane was lower than that of the (100) and (010) planes.
Mechanical properties, such as flexural strength, fracture toughness and ductility, and superconducting properties, Tc, Jc and Hirr, are crucial for industrial applications of high-Tc oxide superconductors. However, oxide superconductors have the intrinsic brittleness of the perovskite structure, thus the strength and the fracture toughness of the materials are low and anisotropic. Therefore, it is very important to study and improve mechanical properties to achieve structural reliability for ap
Since the commercialization of rechargeable Li ion batteries in the early 1990 s, the performance of these devices has continually improved. In such batteries, graphite is typically used as the negative electrode and the present work examined the reaction mechanisms at graphite negative electrodes based on operando synchrotron X-ray diffraction analyses during charge/discharge. The resulting in-plane diffraction patterns of the Li-intercalated graphite permitted a detailed analysis of changes in
The emergence of small interfering RNA (siRNA) opened a new opportunity to study gene functions in a genome. However, large-scale loss-of-function analyses further require cell-based high-throughput methods that allow simultaneous silencing of the huge number of genes by siRNA. In this study, we aim at fabricating the cell-based siRNA arrays that facilitate parallel introduction of multiple siRNAs into cultured mammalian cells. The siRNA arrays were prepared using surface chemical processes incl
Pancreatic β-cell mass (BCM) has a central importance in the pathophysiology of diabetes mellitus. Recently, pancreatic β-cell-specific imaging, especially positron emission tomography (PET) with exendin-based probes, has emerged for non-invasive evaluation of BCM. We developed a novel exendin-based probe labeled with fluorine-18, [<sup>18</sup>F]FB(ePEG12)12-exendin-4 (<sup>18</sup>F-Ex4) for PET imaging. We subsequently conducted a first-in-human phase 1 study of <sup>18</sup>F-Ex4 PET/compute
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