Yonsei University · 医学
Professor Ho-Keun Kwon's research lab focuses on immunomodulation through probiotics and natural plant extracts, with a central emphasis on regulatory T cells (Tregs) and dendritic cell-mediated immune tolerance. The lab investigates how specific probiotic mixtures and cinnamon extracts can induce regulatory immune cells, suppress pro-inflammatory responses, and exert anti-tumor and anti-inflammatory effects both in vitro and in vivo. Key research directions include the molecular mechanisms of Foxp3+ Treg induction, the role of regulatory dendritic cells, and the therapeutic potential of natural compounds in autoimmune diseases and cancer.
Figures are computed from collected data and may differ slightly.
The beneficial effects of probiotics have been described in many diseases, but the mechanism by which they modulate the immune system is poorly understood. In this study, we identified a mixture of probiotics that up-regulates CD4(+)Foxp3(+) regulatory T cells (Tregs). Administration of the probiotics mixture induced both T-cell and B-cell hyporesponsiveness and down-regulated T helper (Th) 1, Th2, and Th17 cytokines without apoptosis induction. It also induced generation of CD4(+)Foxp3(+) Tregs
Our study suggests that anti-tumor effect of cinnamon extracts is directly linked with enhanced pro-apoptotic activity and inhibition of NFkappaB and AP1 activities and their target genes in vitro and in vivo mouse melanoma model. Hence, further elucidation of active components of cinnamon extract could lead to development of potent anti-tumor agent or complementary and alternative medicine for the treatment of diverse cancers.
The beneficial effects of probiotics have been described in many diseases, but the mechanism by which they modulate the immune system is poorly understood. In this study, we identified a mixture of probiotics that up-regulates CD4+Foxp3+ regulatory T cells (Tregs). Administration of the probiotics mixture induced both T-cell and B-cell hyporesponsiveness and down-regulated T helper (Th) 1, Th2, and Th17 cytokines without apoptosis induction. It also induced generation of CD4+Foxp3+ Tregs from th
Our study suggests the potential of cinnamon extract as an anti-inflammatory agent by targeting the generation of regulatory APCs and IL-10(+) regulatory T cells.
Probiotics, live microorganisms that confer health benefits when consumed in adequate amounts, have gained significant attention for their potential therapeutic applications. The beneficial effects of probiotics are believed to stem from their ability to enhance intestinal barrier function, inhibit pathogens, increase beneficial gut microbes, and modulate immune responses. However, clinical studies investigating the effectiveness of probiotics have yielded conflicting results, potentially due to
Significance The transcription factor FoxP3 defines and controls regulatory T cells (Tregs), themselves essential components of immunoregulatory pathways. From a highly granular scanning mutagenesis, the results of our study point to very integrated functions of the protein’s domains, quite different from predictions of simple modular models. The phenotype of mutant mice carrying subtle mutations in Foxp3, which deviate from the acute lymphoproliferation and autoimmunity linked to Treg deficienc
<i>ETS1</i> has shown dichotomous roles as an oncogene and a tumor suppressor gene in diverse cancers, but its functionality in breast cancer tumorigenesis still remains unclear. We utilized the Cancer Genome Atlas (TCGA) database to analyze comprehensive functions of <i>ETS1</i> in human breast cancer (BRCA) patients by investigating its expression patterns and methylation status in relation to clinical prognosis. <i>ETS1</i> expression was significantly diminished by hyper-methylation of the <
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