東京大学 · 神経科学
Hokto Kazama教授の研究室では、ハエをモデル生物として用い、嗅覚・味覚の統合メカニズムや、報酬価値の動的評価を支える神経回路の働きを、結合接続マップ（connectome）を基盤にした神経ネットワークモデルと生体内イメージングを融合して解明しています。特に、ドーパミン神経細胞が感覚刺激の本能的価値を継続的に評価・更新する仕組みや、嗅覚刺激が味覚神経に直接作用する新たな感覚統合機構の解明を進めています。
Figures are computed from collected data and may differ slightly.
Abstracts of the 25th Annual Computational Neuroscience\nMeeting: CNS-2016\nSeogwipo City, Jeju-do, South Korea. 2–7 July 2016
The Drosophila antennal lobe is organized into glomerular compartments, where olfactory receptor neurons synapse onto projection neurons. Projection neuron dendrites also receive input from local neurons, which interconnect glomeruli. In this study, we investigated how activity in this circuit changes over time when sensory afferents are chronically removed in vivo. In the normal circuit, excitatory connections between glomeruli are weak. However, after we chronically severed receptor neuron axo
Dopaminergic neurons (DANs) drive associative learning to update the value of sensory cues, but their contribution to the assessment of sensory values outside the context of association remains largely unexplored. Here, we show in Drosophila that DANs in the mushroom body encode the innate value of odors and constantly update the current value by inducing plasticity during olfactory maneuver. Our connectome-based network model linking all the way from the olfactory neurons to DANs reproduces the
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