Seoul National University · 医学
Professor Hyewon Lee's research lab focuses on the environmental and public health impacts of air pollution, particularly its effects on neurological and respiratory diseases. The lab investigates the short- and long-term associations between ambient air pollutants—such as PM₂.₅, NO₂, and O₃—and the incidence or exacerbation of conditions including Parkinson’s disease, Alzheimer’s disease, ALS, migraine, and nontuberculous mycobacterial (NTM) infections. A key research direction involves understanding how environmental stressors, including dust storms and high temperatures, interact with air pollution to influence health outcomes, especially in urban and aging populations. The lab also contributes to public health policy by identifying modifiable risk factors and informing preventive strategies.
Figures are computed from collected data and may differ slightly.
The prevalence and incidence of nontuberculous mycobacterial (NTM) infections increased in South Korea from 2007 to 2016. Annual prevalence of NTM infection increased to 39.6 cases/100,000 population in 2016 and annual incidence to 19.0 cases/100,000 population. Overall prevalence for the study period was higher in the elderly, in females, and in cities.
Increasing experimental evidence has suggested air pollution as new risk factor for neurological disease. Although long-term exposure is reportedly related to neurological disease, information on association with short-term exposure is scarce. We examined the association of short-term exposure to particles <2.5 μm (PM<sub>2.5</sub>), nitrogen dioxide (NO<sub>2</sub>), sulfur dioxide (SO<sub>2</sub>), ozone (O<sub>3</sub>), and carbon monoxide (CO) with PD aggravation in Seoul from the National H
Our study provides new evidence that air pollution exposure may trigger migraine especially on high-temperature days, and this finding may contribute in establishing preventive measures against migraine.
Red blood cell distribution width (RDW) is a parameter reported in complete blood cell count tests, and has been reported as an inflammatory biomarker. Multiple myeloma (MM) is known to be associated with inflammatory microenvironments. However, the importance of RDW has been seldom studied in MM. For this study, 146 symptomatic myeloma patients with available RDW at diagnosis were retrospectively reviewed, and their characteristics were compared between two groups, those with high (>14.5%) a
While previous person-centered models in dentistry focused on the role of providers within the clinical setting, this work emphasizes the role of the care designer in creating an environment where both person and provider are able to communicate effectively and achieve improved health outcomes.
Selective cell ablation can be used to identify neuronal functions in multicellular model organisms such as Caenorhabditis elegans. The optogenetic tool KillerRed facilitates selective ablation by enabling light-activated damage of cell or subcellular components in a temporally and spatially precise manner. However, the use of KillerRed requires stimulating (5 min-1 h), culturing (~24 h) and imaging (often repeatedly) a large number of individual animals. Current manual manipulation methods are
We provide new evidence that exposure to short-term air pollution may increase the risk of acute exacerbation of ALS. Further studies are warranted to understand the underlying mechanisms.
The need for self-generating energy for outdoor environments is growing. To cope with emergencies in outdoor environments, sustainable, environment-independent energy-harvesting methods based on natural human movements are necessary. In this study, we developed a wearable energy-harvesting textile with a structure capable of generating the maximum energy from the swinging motion that occurs during walking. Two types of conductive yarn were manufactured and, when used as coils, are as durable as
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