Seoul National University · 医学
Professor Hyuk-Soo Han's research lab specializes in clinical orthopedic research with a focus on total knee arthroplasty (TKA) outcomes, implant design, and biomechanical factors influencing prosthesis longevity. The lab investigates complications such as aseptic loosening, wound healing in diabetic patients, and accurate anatomical measurements—particularly posterior tibial slope—using advanced imaging techniques. Their work emphasizes improving surgical techniques, implant fixation, and patient-specific anatomical alignment to enhance functional recovery and reduce revision rates in knee replacement surgery.
Figures are computed from collected data and may differ slightly.
We have examined the results obtained with 72 NexGen legacy posterior stabilised-flex fixed total knee replacements in 47 patients implanted by a single surgeon between March 2003 and September 2004. Aseptic loosening of the femoral component was found in 27 (38%) of the replacements at a mean follow-up of 32 months (30 to 48) and 15 knees (21%) required revision at a mean of 23 months (11 to 45). We compared the radiologically-loose and revised knees with those which had remained well-fixed to
Level III Therapeutic study.
Poorly controlled hyperglycemia before surgery may increase the incidence of wound complications among diabetic patients after TKA.
Abstract The authors aimed to demonstrate the relationship between the sagittal mechanical axis of the tibia and other reference axes of the tibia and fibula in patients with advanced osteoarthritis of the knee joints, and then to identify a reliable landmark in order to minimize posterior tibial slope measurement errors. We evaluated 133 osteoarthritic knees with neutral or varus deformity in 64 female and 8 male patients. Axial computed tomographic images of whole tibiae including knee and ank
With retrograde intramedullary nailing, excellent fracture union and good functional recovery were obtained in patients with periprosthetic supracondylar fractures.
IV.
The validity and reliability of the Musculoskeletal Tumor Society functional evaluation system were evaluated using the Nottingham Health Profile, the Short Form-36, and the EuroQol protocol to measure the quality of life of patients with malignant musculoskeletal tumors. Forty-nine patients were assessed and osteosarcoma around the knee was the most common type of tumor. Prosthetic reconstructions had been done in 55.1% of patients. In a content validity analysis, neither social nor psychologic
Overall midterm high-flexion TKA survival in our Asian cohort was lower than that of conventional and other high-flexion designs. This unusually high rate of femoral component loosening was associated with postoperative high-flexion activities.
III.
We undertook this study to characterize changes in the proliferative capacities, chondrogenic phenotypes, and gene expression profiles of human synovium-derived progenitor cells from osteoarthritic patients during in vitro expansion. Cells isolated from osteoarthritic synovia were cultured, and growth rates during serial passages were evaluated. Surface molecule expressions were determined by flow cytometry and cytogenetic analyses were performed. After chondrogenic differentiation in cell pelle
This study aimed to evaluate growth factor concentration in platelet-rich plasma (PRP) (leukocyte-rich PRP) based on storage temperature, duration of storage, and method of activation. PRP samples were stored at 24℃ (room temperature group), 4℃ (refrigerator group), and -70℃ (deep-freezer group). In each temperature, four aliquots were prepared based on the time of analysis (immediately, 1, 3, and 7 days after preparation). After storage, concentrations of platelet-derived growth factor-AA (PDGF
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