東京大学 · 生化学・遺伝学・分子生物学
Hyun Jin Kim教授の研究室は、がんや神経変性疾患を標的にした核酸医薬の効果的かつ安全な体内送達を目的として、スマートなナノデリバリー系の設計と開発を主軸としています。特に、siRNA やmRNA の細胞内効果的送達を実現するためのpH応答性ポリマー、金ナノ粒子を用いたサイズ制御型ナノコンプレックス、および還体型リンクを有するブロックコポリマーを用いたスマートなポリプレックス系の開発が進んでいます。また、神経変性疾患関連タンパク質のアミロイド化機構の解明にも取り組んでおり、ナノスケールの自己集合構造の制御を目的としています。
Figures are computed from collected data and may differ slightly.
For systemic siRNA delivery into tumor tissues, a safe and efficient vehicle is strongly required. Therefore, we designed a block copolymer of detachable poly(ethylene glycol) (PEG) polycation bearing low pKa amines and hydrophobic moieties in the side chain to develop a smart siRNA complex possessing biocompatibility, high complex stability, and endosomal escaping functionality. A disulfide linkage (-SS-) was inserted as a linker between PEG and a cationic polyaspartamide derivative, poly{N-[N-
Small interfering RNA (siRNA) drugs have been considered to treat various diseases in major organs. However, siRNA drugs developed for cancer therapy are hindered from proceeding to the clinic. To date, various delivery formulations have been developed from cationic lipids, polymers, and/or inorganic nanoparticles for systemic siRNA delivery to solid tumors. Most of these delivery vehicles do not generate small particle sizes and pharmacokinetics required for accumulation in target cancer cells
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