Yonsei University · 医学
Professor Hyung Woo Kim's research lab focuses on clinical and translational studies in nephrology, oncology, and environmental health, with a strong emphasis on identifying biomarkers and predictive models for disease progression. The lab investigates inflammatory markers in pancreatic cancer, dialysis adequacy using machine learning, and risk factors for post-surgical complications such as gallstone formation. Additionally, the lab explores the immunomodulatory effects of micronutrients like vitamin C on dendritic cells, linking basic immunology to clinical outcomes. Their work bridges clinical medicine with data science and pathophysiology to improve patient outcomes in chronic and acute diseases.
Figures are computed from collected data and may differ slightly.
Low urinary potassium excretion is associated with progression of CKD.
Several reports showed that interleukin-6 (IL-6) or -8 (IL-8) might be useful inflammatory biomarkers for pancreatic ductal adenocarcinoma (PDAC), although these clinical impact is still open to debate. The aim of this study was to elucidate whether serum levels of IL-6 and IL-8 at diagnosis could predict the tumor progression pattern of PDAC, especially in extensive hepatic metastasis.According to the tumor burden of hepatic metastasis at the last follow-up, tumor progression pattern was define
Abstract A heavy rainfall event induced by mesoscale convective systems (MCSs) occurred over the middle Korean Peninsula from 25 to 27 July 1996. This heavy rainfall caused a large loss of life and property damage as a result of flash floods and landslides. An observational study was conducted using Weather Surveillance Radar-1988 Doppler (WSR-88D) data from 0930 UTC 26 July to 0303 UTC 27 July 1996. Dominant synoptic features in this case had many similarities to those in previous studies, such
Dialysis adequacy is an important survival indicator in patients with chronic hemodialysis. However, there are inconveniences and disadvantages to measuring dialysis adequacy by blood samples. This study used machine learning models to predict dialysis adequacy in chronic hemodialysis patients using repeatedly measured data during hemodialysis. This study included 1333 hemodialysis sessions corresponding to the monthly examination dates of 61 patients. Patient demographics and clinical parameter
Previous studies reported increased incidence of gallstone formation after gastrectomy. However, there were few reports about factors other than surgical technique. The purpose of this study is to investigate the spectrum of risk factors of gallstone formation after gastrectomy. From June 2003 to December 2008, 1480 patients who underwent gastrectomy due to gastric cancer but had no gallstones before surgery were identified. Electronic medical records were retrospectively reviewed. Gallstones we
Few studies have evaluated the presence of hepatic or peritoneal metastasis as a prognostic factor in patients with metastatic pancreatic ductal adenocarcinoma (PDAC). This study aimed to elucidate the prognostic value of the initial metastatic, extrahepatic, or hepatic site in patients with metastatic PDAC. Between January 2007 and December 2013, the medical records of 343 patients with metastatic PDAC treated at Seoul National University Bundang Hospital were retrospectively reviewed. Patients
Vitamin C is an essential water-soluble nutrient which primarily exerts its effect on host defense mechanisms and immune homeostasis, but the mechanism related to immune-potentiation is poorly understood. Since dendritic cells (DCs) are known as a potent antigen presenting cell (APC) that could enhance the antigen specific immune responses, we investigate the effects of vitamin C on activation of DCs and its related mechanism by using dendritic cell lines, DC-1. First, we found that there was no
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