Sungkyunkwan University · 情報科学
Professor Hyunwoo Lee's research lab focuses on molecular microbiology, neuroscience, and neurodegenerative diseases, with a central emphasis on signal transduction pathways in bacterial antibiotic resistance, synaptic organization and spine morphogenesis, and the role of phosphoinositide signaling in neuronal function and neurodegeneration. The lab investigates key regulatory systems such as the PmrA/PmrB two-component system in *Salmonella*, postsynaptic scaffolding proteins like PSD-95 and their interactors (e.g., Preso), and lipid phosphatases such as MTMR2 in neuronal health and disease. The lab integrates molecular biology, cell biology, and biochemical approaches to understand disease mechanisms and identify potential therapeutic targets in infections and neurological disorders.
Figures are computed from collected data and may differ slightly.
The PmrA/PmrB regulatory system of Salmonella enterica controls the modification of lipid A with aminoarabinose and phosphoethanolamine. The aminoarabinose modification is required for resistance to the antibiotic polymyxin B, as mutations of the PmrA-activated pbg operon or ugd gene result in strains that lack aminoarabinose in their lipid A molecules and are more susceptible to polymyxin B. Additional PmrA-regulated genes appear to participate in polymyxin B resistance, as pbgP and ugd mutants
PSD-95 is an abundant postsynaptic density (PSD) protein involved in the formation and regulation of excitatory synapses and dendritic spines, but the underlying mechanisms are not comprehensively understood. Here we report a novel PSD-95-interacting protein Preso that regulates spine morphogenesis. Preso is mainly expressed in the brain and contains WW (domain with two conserved Trp residues), PDZ (PSD-95/Dlg/ZO-1), FERM (4.1, ezrin, radixin, and moesin), and C-terminal PDZ-binding domains. The
Despite growing interest in studying the metaverse, a theory-driven investigation into the factors that contribute to an enjoyable metaverse experience remains scarce. The current study examined the impacts of avatar identification, social engagement, and avatar customization on users' enjoyment of the metaverse based on the impression management theory. A total of 301 metaverse users were recruited for the study. The hypothesized models of mediation effect of social engagement and moderation ef
Following IA/aHSCT, MS patients showed accelerated whole-brain atrophy that was likely associated with treatment-related toxicity and degeneration of "committed" tissues. Atrophy eventually slowed to that expected from normal aging, suggesting that stopping inflammatory activity in MS can reduce secondary degeneration and atrophy.
MTMR2 is a 3-phosphatase specific for the phosphoinositides PI(3)P and PI(3,5)P(2), which are mainly present on endosomes. Mutations in the MTMR2 gene in Schwann cells lead to a severe demyelinating peripheral neuropathy known as Charcot-Marie-Tooth disease type 4B1. MTMR2 expression is also detected in peripheral and central neurons, but neural functions of MTMR2 remain unclear. Here, we report that MTMR2 is localized to excitatory synapses of central neurons via direct interaction with PSD-95,
Transport Layer Security (TLS) has become the norm for secure communication over the Internet. In August 2018, TLS 1.3, the latest version of TLS, was approved, providing improved security and performance of the previous TLS version. In this paper, we take a closer look at TLS 1.3 deployments in practice regarding adoption rate, security, performance, and implementation by applying temporal, spatial, and platform-based approaches on 687M connections.
Two piloquinone derivatives isolated from <i>Streptomyces</i> sp. CNQ-027 were tested for the inhibitory activities of two isoforms of monoamine oxidase (MAO), which catalyzes monoamine neurotransmitters. The piloquinone 4,7-dihydroxy-3-methyl-2-(4-methyl-1-oxopentyl)-6H-dibenzo[b,d]pyran-6-one (1) was found to be a highly potent inhibitor of human MAO-B, with an IC<sub>50</sub> value of 1.21 µ; in addition, it was found to be highly effective against MAO-A, with an IC<sub>50</sub> value of 6.47
Abstract PS2.M, an 18-nucleotide DNA molecule, has been shown to be a dual enzyme for porphyrin metallation and, when complexed with hemin, for peroxidation. To date, detailed information has not been available on either the actively folded structure of PS2.M or on the contribution of specific nucleotides within it toward the peroxidase activity. Here, we report a variety of experiments that probe the structure and function of PS2.M as well as of a number of point mutants of PS2.M. Based on thes
Chemotherapy-related toxicity affected both GM and WM. WM was further affected by focal T1-weighted lesion-related pathologies. Long-term rates of GM and WM atrophy were comparable to those of normal-aging.
Intradural lumbar disc herniation is a rare disease. According to the reports of intradural lumbar disc herniations, most cases have developed as a chronic degenerative disc diseases. Traumatic intradural lumbar disc herniations are even rarer. A 52-year-old man visited our emergency center with numbness in his left calf and ankle after falling accident. Initial impression by radiologic findings was a spinal subdural hematoma at the L1 level. A follow up image two weeks later, however, did not d
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