Yonsei University · 医学
Professor Jae Myun Lee's research lab focuses on viral pathogenesis, particularly the molecular mechanisms of Epstein-Barr virus (EBV) and its interactions with host cell signaling pathways. The lab investigates viral oncoproteins like EBNA2 and their roles in B-cell immortalization, apoptosis evasion, and immune evasion, with a strong emphasis on host-virus interactions involving transcription factors such as Nur77. Additionally, the lab explores vaccine development, including microneedle-based delivery systems for viral vaccines, and examines host genetic factors influencing drug response, particularly in antidepressant therapy via MRP1 polymorphisms. The research integrates virology, immunology, and translational medicine to uncover novel therapeutic targets and strategies.
Figures are computed from collected data and may differ slightly.
Epstein-Barr virus infection in vitro immortalizes primary B cells. EBNA2 is an Epstein-Barr virus-encoded transcriptional transactivator that mimics the effects of activated Notch signaling and is essential for this proliferative response. An assay using Sindbis virus (SV) as a cell death inducer revealed that, like Notch, EBNA2 also has antiapoptotic activity. We show that Nur77 is a mediator of SV-induced cell death and that EBNA2 antiapoptotic activity results from interaction with Nur77. EB
Reduction of CD56(bright) cells may precede NK cell dysfunction, leading to impaired cytotoxicity against PCa cells. These observations may explain one of the mechanisms behind NK cell dysfunction observed in PCa microenvironment and lend support to the development of future cancer immunotherapeutic strategies.
Although smallpox has been eradicated globally, the potential use of the smallpox virus in bioterrorism indicates the importance of stockpiling smallpox vaccines. Considering the advantages of microneedle-based vaccination over conventional needle injections, in this study, we examined the feasibility of microneedle-based smallpox vaccination as an alternative approach for stockpiling smallpox vaccines. We prepared polylactic acid (PLA) microneedle array patches by micromolding and loaded a seco
The replication of flaviviruses results in the secretion of four virus-coded proteins into the extracellular environment. Three of these proteins, E, C and M (or pre-M), are found in purified virions. A fourth virus-specified extracellular protein which was not present in either the slowly sedimenting haemagglutinin particles or in virions is described. The relationship of this protein to the intracellular NS1 polypeptide was investigated along with its similarity to the soluble complement-fixin
Multidrug resistance protein 1 (MRP1, ABCC1) transports antidepressive agents in the endothelial cells of the blood-brain barrier. Therefore, polymorphisms in the MRP1 gene may affect the treatment response of antidepressants. This study was aimed to identify the association between genetic variations in MRP1/ABCC1 and the therapeutic response to the antidepressant citalopram. One hundred and twenty-three patients who had been treated with citalopram monotherapy to control their major depressive
In addition to functioning as a transcriptional transactivator, Epstein-Barr virus EBNA2 interacts with Nur77 to protect against Nur77-mediated apoptosis. Estrogen-regulated EBNA2 in EREB2-5 cells was replaced by either EBNA2 or EBNA2 with a deletion of conserved region 4 (EBNA2DeltaCR4). Both EBNA2-converted and EBNA2DeltaCR4-converted EREB2-5 cells grew in the absence of estrogen and expressed LMP1. Treatment with tumor necrosis factor alpha did not induce apoptosis of EBNA2- or EBNA2DeltaCR4-
In this paper, we study multirate transversal adaptive digital filters (ADF's) based on the block least-mean-square (BLMS) algorithms. These include an ADF with decimation (ADFD) and an ADF with interpolation (ADFI). We first formulate these filters based on the block mean-squared error (BMSE) criterion and derive BLMS multi-rate weight-adjustment algorithms, and then study efficient realization of those filters. It is shown that the BLMS ADFD can be realized efficiently in the direct form or in
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