Sungkyunkwan University · 医学
Professor Jae-Hoon Ko's research lab focuses on infectious disease immunology, particularly host immune responses to emerging viral pathogens such as SARS-CoV-2 and human adenovirus (HAdV). The lab investigates T cell and antibody responses in vaccinated and infected individuals, with an emphasis on variant-specific immunity and immune memory. Additionally, the lab explores advanced biomedical imaging and artificial intelligence applications in medical diagnostics, including 3D-aware GANs for image reconstruction and single-image 3D synthesis.
Figures are computed from collected data and may differ slightly.
Most asymptomatic and mild COVID-19 patients produced the neutralizing antibody, although the titers were lower than pneumonia patients. ELISA and FIA sensitively detected anti-SARS-CoV-2 antibodies.
Steroid use and RBC transfusion within 1 month of the diagnosis of colitis were independent risk factors for development of CMV colitis in immunocompetent hosts.
With the recent advances in NeRF-based 3D aware GANs quality, projecting an image into the latent space of these 3D-aware GANs has a natural advantage over 2D GAN inversion: not only does it allow multi-view consistent editing of the projected image, but it also enables 3D reconstruction and novel view synthesis when given only a single image. However, the explicit viewpoint control acts as a main hindrance in the 3D GAN inversion process, as both camera pose and latent code have to be optimized
A large HAdV outbreak is currently ongoing in the Korean military, with a trend away from seasonality, and HAdV-55 is likely the predominant strain. Persistent efforts to control the outbreak, HAdV type-specific surveillance, and vaccine development are required.
Here, we examine peripheral blood memory T cell responses against the SARS-CoV-2 BA.4/BA.5 variant spike among vaccinated individuals with or without Omicron breakthrough infections. We provide evidence supporting a lack of original antigenic sin in CD8<sup>+</sup> T cell responses targeting the spike. We show that BNT162b2-induced memory T cells respond to the BA.4/BA.5 spike. Among individuals with BA.1/BA.2 breakthrough infections, IFN-γ-producing CD8<sup>+</sup> T cell responses against the
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