Yonsei University · 医学
Professor Jeong Yoon Park's research lab specializes in spinal disorders, with a focus on degenerative spinal diseases, including ossification of the posterior longitudinal ligament (OPLL), spondylolisthesis, and adjacent-segment degeneration (ASD). The lab investigates the genetic, biomechanical, and molecular mechanisms underlying spinal degeneration and aging, integrating clinical spine surgery with molecular biology and genetic analysis. Key research directions include the role of pelvic parameters in spinal sagittal balance, gene expression profiles in intervertebral disc degeneration, and the genetic susceptibility to spinal and systemic diseases such as lung cancer and premature aging. The lab also explores DNA repair pathways and their implications in aging and cancer, particularly through animal models of nucleotide excision repair deficiency.
Figures are computed from collected data and may differ slightly.
Patients having cervical surgery for OPLL should also undergo simultaneous studies of the thoracic spine looking for tandem OPLL and/or OLF. The frequency of tandem lesions in this series was 23 of 68, with 6 requiring subsequent surgery for an evolving thoracic myelopathic deficit.
The purpose of this study was to evaluate the correlation between adjacent-segment degeneration (ASD) and pelvic parameters in the patients with spondylolytic spondylolisthesis. Sagittal balance is the most important risk and prognostic factor in the development of ASD. The pelvic incidence angle (PIA) is an important anatomical parameter in determining the sagittal curvature of the spine and in the individual variability of the sacral slope and the lordotic curve. Thus, the authors evaluated th
Study Design The 2 groups of living human nucleus pulposus were prospectively compared according to disc degeneration. Objectives This study was conducted to investigate the expressions of various genes associated with matrix synthesis and expressions of inflammatory cytokines-associated genes according to degrees of disc degeneration in human discs. Summary of Background Data Degenerated discs were obtained from 18 patients who underwent discectomy for lumbar disc herniation. Disc degeneration
If caudal and cranial ASD are considered, the overall occurrence rate of ASD increases to 50%. The incidence rate of caudal ASD at L5-S1 was significantly lower than that of cranial ASD. Furthermore, the occurrence of caudal ASD was found to be significantly correlated with pre-existing disc degeneration.
The human microsomal epoxide hydrolase (EH) gene contains polymorphic alleles, which may be linked to increased risk for tobacco-related lung cancer. The purpose of this study is to screen new polymorphisms and determine whether these polymorphisms can be used to predict individual susceptibility to lung cancer. The polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis was used to screen for polymorphisms in the coding region of the EH gene. Eleven polymorphisms,
Unrepaired or misrepaired DNA damage has been implicated as a causal factor in cancer and aging. Xpd(TTD) mice, harboring defects in nucleotide excision repair and transcription due to a mutation in the Xpd gene (R722W), display severe symptoms of premature aging but have a reduced incidence of cancer. To gain further insight into the molecular basis of the mutant-specific manifestation of age-related phenotypes, we used comparative microarray analysis of young and old female livers to discover
The deep learning application is effective for spinal implant identification. This demonstrates that clinicians can use ML-based deep learning applications to improve clinical practice and patient care.Level of Evidence: 3.
Minimally invasive surgery with a transforaminal lumbar interbody fusion (MIS TLIF) is an important minimally invasive fusion technique for the lumbar spine. Lumbar spine reoperation is challenging and is thought to have greater complication risks. The purpose of this study was to compare MIS TLIF with unilateral screw fixation perioperative results between primary and revision surgeries. This was a prospective study that included 46 patients who underwent MIS TLIF with unilateral pedicle screw.
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