名古屋大学 · 工学
Jiro Kasahara教授の研究室では、神経細胞内のカルシウムシグナル伝達機構、特にカルモジュリン依存性キナーゼ（CaMK）の機能と調節機構に焦点を当てた神経細胞生物学的研究を行っています。特に、CA1海馬における長期増強（LTP）の分子機構としてのCaMKIVの役割や、CREBリン酸化との関連が解明されており、学習・記憶の基盤を解明する基盤的研究を推進しています。また、神経シグナル伝達におけるキナーゼ・ホスファターゼのバランスや、神経可塑性の分子メカニズムの解明を目的としています。
Figures are computed from collected data and may differ slightly.
The importance of well characterized calcium/calmodulin-dependent protein kinase (CaMK) II in hippocampal long term potentiation (LTP) is widely well established; however, several CaMKs other than CaMKII are not yet clearly characterized and understood. Here we report the activation of CaMKIV, which is phosphorylated by CaMK kinase and localized predominantly in neuronal nuclei, and its functional role as a cyclic AMP-responsive element-binding protein (CREB) kinase in high frequency stimulation
journal article
journal article
How to generate a steady-state detonation around a hypersonic projectile in stoichiometric hydrogen-oxygen premixed gases is studied. The speed of the hypersonic projectiles was beyond the Chapman ‐Jouguet(C‐J) detonation speed. The e owe eld around the projectile was visualized by using a gate intensie ed charge-coupled device camera(single-frame schlieren picturesand OHradical self-emissionimages ). Threeparameters are varied:1 ) the projectile e ight length from diaphragm rupture location, 2
Calcium/calmodulin-dependent protein kinases (CaM kinases) are major multifunctional enzymes that play important roles in calcium-mediated signal transduction. To characterize their regulatory mechanisms in neurons, we compared glutamate-induced phosphorylation of CaM kinase IV and CaM kinase II in cultured rat hippocampal neurons. We observed that dephosphorylation of these kinases followed different time courses, suggesting different regulatory mechanisms for each kinase. Okadaic acid, an inhi
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