Kyung Hee University · 材料科学
Professor Joohoon Kim's research lab specializes in the design and synthesis of functional nanomaterials with tailored catalytic and biorecognition properties. The lab focuses on dendrimer-encapsulated nanoparticles, particularly platinum-based systems, for applications in bio-mimetic sensing, enzymatic activity modulation, and advanced imaging technologies. Key research directions include the development of nanozymes for colorimetric and fluorescence-based detection, the integration of nanomaterials with biological molecules for hybrid biosensors, and the application of machine learning to enhance nanophotonic devices such as metalenses. The lab also explores high-throughput screening methods for enzyme substrate specificity and innovative nanofabrication techniques for multifunctional nanostructures.
Figures are computed from collected data and may differ slightly.
We demonstrate the feasible use of Pt nanoparticles encapsulated inside amine-terminated fourth-generation polyamidoamine dendrimers as peroxidase-mimetic labels for sensitive colorimetric assays. This was performed by utilizing intrinsic dual functionalities of the dendrimer-encapsulated Pt nanoparticles, i.e. peroxidase-like activity and multiple conjugation sites.
Recent advances in metasurface lenses (metalenses) have shown great potential for opening a new era in compact imaging, photography, light detection, and ranging (LiDAR) and virtual reality/augmented reality applications. However, the fundamental trade-off between broadband focusing efficiency and operating bandwidth limits the performance of broadband metalenses, resulting in chromatic aberration, angular aberration, and a relatively low efficiency. A deep-learning-based image restoration frame
This article describes a method for the global profiling of the substrate specificities of DNA ligases and illustrates examples using the Taq and T4 DNA ligases. The method combines oligonucleotide arrays, which offer the benefits of high throughput and multiplexed assays, with mass spectrometry to permit label-free assays of ligase activity. Arrays were prepared by immobilizing ternary biotin-tagged DNA substrates to a self-assembled monolayer presenting a layer of streptavidin protein. The arr
Turn-on type fluorescence sensing of O<sub>2</sub> is considered a promising approach to developing ways to measure O<sub>2</sub> in microenvironments with spatially distributed O<sub>2</sub> levels. As a class of nanomaterials with a high degree of control over composition and structure, dendrimer-encapsulated nanoparticles (DENs) are promising candidates to mimic biological enzymes. Here, we report a strategy to monitor spatially distributed O<sub>2</sub> across a three-dimensional (3D) human
We demonstrate a method for constructing bifunctional nanostructures, which conjugate biochemical and electrocatalytic activities, on glassy carbon surfaces by decorating the carbon surfaces with both biologically active glucose oxidases and size-monodisperse Pt nanoparticles (less than 2 nm in diameter) utilizing only a single dendrimer layer.
A chemosensor compound (1) consisting of a central ferrocene with two butylaminomethyl arms showed unexpected facile electrochemical oxidation of the secondary amines in proximity to the ferrocene, which was utilized for electrochemical discrimination of phthalic acid selectively over two other isomers, isophthalic acid and terephthalic acid.
In this study, we report the controllable synthesis of dendrimer-encapsulated Pt nanoparticles (Pt DENs) utilizing repetitively coupled chemical reduction and galvanic exchange reactions. The synthesis strategy allows the expansion of the applicable number of Pt atoms encapsulated inside dendrimers to more than 1000 without being limited by the fixed number of complexation sites for Pt<sup>2+</sup> precursor ions in the dendrimers. The synthesis of Pt DENs is achieved in a short period of time (
We report the electrochemical grafting of amine-terminated dendrimers encapsulating nanoparticles onto indium tin oxide (ITO) surfaces.
Abstract Enhanced electrochemiluminescence (ECL) of luminol was reported with the use of dendrimer‐encapsulated Au nanoparticle (Au DEN)‐modified ITOs in the presence of hydrogen peroxide, which was applied for sensitive ECL‐based electroanalysis of hydrogen peroxide. The enhanced ECL of luminol in the presence of hydrogen peroxide was attributed to facile electrochemical oxidation of luminol/hydrogen peroxide on the Au DEN‐modified ITOs at potentials as low as ∼0.4 V (vs. Ag/AgCl). Spooling ECL
Abstract We report the electrochemiluminescence (ECL) of water‐soluble individual Au nanoclusters (Au NCs) fractionated by polyacrylamide gel electrophoresis of Au NCs synthesized using glutathione. The individual Au NCs demonstrated unique and significant differences in ECL. Interestingly, they exhibited near‐infrared (near‐IR) ECL that became dominant when the ratio of Au(I) to Au(0) decreased in the individual Au NCs. This indicated that the oxidation states of Au NCs primarily affected the E
In this work, we report a bipolar electrode (BPE) array system with self-driven optical readouts of the faradic current flowing through the BPEs. The BPE array system is based on the spontaneous redox reactions that are respectively occurring at opposite poles of the BPEs with appropriate electrocatalysts on the poles; this system is analogous to one consisting of galvanic electrochemical cells. The galvanic BPE array system operates in a self-powered mode that requires there to be neither a dir
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