Seoul National University · 医学
Professor Jun-Bean Park's research lab specializes in cardiovascular imaging and biomarker discovery, focusing on non-invasive diagnostic methods and prognostic indicators for coronary artery disease and pulmonary hypertension. The lab integrates advanced medical imaging techniques—such as CT angiography, cardiac MRI, and PET—with hemodynamic and biochemical markers to improve risk stratification and early detection of atherosclerotic and vascular diseases. Key research directions include assessing arterial stiffness, plaque vulnerability, and inflammatory processes in the vasculature using innovative imaging agents and computational hemodynamics. The lab also investigates metabolic and systemic biomarkers, such as alkaline phosphatase and lipid profiles, to predict adverse cardiovascular outcomes in interventional and structural heart disease patients.
Figures are computed from collected data and may differ slightly.
The cCTA-based CFD method can improve the identification of high-risk plaques and the risk stratification for coronary artery disease patients by providing non-invasive measurements of WSS affecting coronary plaques.
Our study demonstrated that the higher serum ALP level is an independent predictor of mortality, myocardial infarction, and stent thrombosis in CAD patients after PCI with DES.
Purpose To explore the prognostic value of cardiac magnetic resonance (MR) imaging in predicting postoperative cardiac death in patients with severe functional tricuspid regurgitation (TR). Materials and Methods This study was approved by the institutional review board, and written informed consent was obtained from all patients. Prospectively collected data included cardiac MR images, New York Heart Association (NYHA) functional class, a comprehensive laboratory test, and clinical events over t
Aim: The cardio-ankle vascular index (CAVI) is an index of arterial stiffness. We investigated the association of CAVI with the severity of coronary artery calcification (CAC) and coronary stenosis by coronary computed tomography angiography (CTA) in an asymptomatic population.Methods: A total of 549 asymptomatic Korean individuals who underwent CAVI and CTA were analyzed retrospectively. CAC and coronary stenosis were measured by CTA and assessed for the correlation with CAVI.Results: The degre
Mildly abnormal baseline lipid levels were associated with an increased future risk of atherosclerotic cardiovascular disease events, particularly MI, whereas measures of lipid variability were not. Therefore, in young adults, achieving optimal lipid levels could be valuable in the prevention of atherosclerotic cardiovascular disease.
<b>Rationale:</b> Diagnosis and monitoring of patients with pulmonary artery hypertension (PAH) is currently difficult.<b>Objectives:</b> We aimed to develop a noninvasive imaging modality for PAH that tracks the infiltration of macrophages into the pulmonary vasculature, using a positron emission tomography (PET) agent, <sup>68</sup>Ga-2-(<i>p</i>-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) mannosylated human serum albumin (MSA), that targets the mannose receptor (
Background Identifying predictive markers for future atherosclerotic cardiovascular diseases may be helpful to motivate young adults to promote healthy lifestyle. We sought to determine the association between persistently elevated low-density lipoprotein-cholesterol (LDL-C) and/or triglyceride levels and the atherosclerotic cardiovascular diseases risks in young adults. Methods and Results We conducted a nationwide population-based cohort study of 1 887 853 statin-naive adults aged 20 to 39 yea
HCM was significantly associated with the risk of incident mental disorders, particularly within 1 year after HCM diagnosis, underscoring the importance of screening mental health problems, including mood and anxiety disorders, in patients with HCM.
ClinicalTrials.gov, NCT02940366 . Registered on 19 October 2016.
Pulmonary hypertension (PH) associated with left heart disease (PH-LHD) is the most common form of PH and has significantly higher morbidity and mortality. We estimated the prevalence of PH-LHD on the follow-up echocardiography and the role of left atrial (LA) function in PH-LHD. From the STRATS-AHF registry composed of 4312 acute heart failure (HF) patients, we analyzed peak atrial longitudinal strain (PALS) in 1729 patients with follow-up echocardiographic examinations during mean 18.1 ± 13.5
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