Korea University · 医学
Professor Jungmin Choi's research lab focuses on understanding the genetic and molecular mechanisms underlying aggressive cancers, particularly uterine leiomyosarcoma and hepatocellular carcinoma, through integrated multi-omics approaches including whole-exome, whole-genome, and RNA sequencing. The lab investigates somatic mutations, copy number variations, and the regulatory roles of non-coding RNAs—especially pseudogene-derived lncRNAs—in cancer progression and chemoresistance. By leveraging large-scale cancer genomics datasets such as TCGA, the lab aims to identify novel therapeutic targets and biomarkers for precision oncology. The research also extends to parasitic protozoa, where functional genomics and systems biology are applied to understand pathogenic mechanisms in trypanosomatids.
Figures are computed from collected data and may differ slightly.
Uterine leiomyosarcomas (uLMS) are aggressive tumors arising from the smooth muscle layer of the uterus. We analyzed 83 uLMS sample genetics, including 56 from Yale and 27 from The Cancer Genome Atlas (TCGA). Among them, a total of 55 Yale samples including two patient-derived xenografts (PDXs) and 27 TCGA samples have whole-exome sequencing (WES) data; 10 Yale and 27 TCGA samples have RNA-sequencing (RNA-Seq) data; and 11 Yale and 10 TCGA samples have whole-genome sequencing (WGS) data. We foun
The decoding of the Tritryp reference genomes nearly 7 years ago provided a first peek into the biology of pathogenic trypanosomatids and a blueprint that has paved the way for genome-wide studies. Although 60-70% of the predicted protein coding genes in Trypanosoma brucei, Trypanosoma cruzi and Leishmania major remain unannotated, the functional genomics landscape is rapidly changing. Facilitated by the advent of next-generation sequencing technologies, improved structural and functional annota
Hepatocellular carcinoma (HCC) records the second-lowest 5-year survival rate despite the avalanche of research into diagnosis and therapy. One of the major obstacles in treatment is chemoresistance to drugs such as 5-fluorouracil (5-FU), making identification and elucidation of chemoresistance regulators highly valuable. As the regulatory landscape grows to encompass non-coding genes such as long non-coding RNAs (lncRNAs), a relatively new class of lncRNA has emerged in the form of pseudogene-d
Open papers in the app to read, cite, and organize with AI.
