慶應義塾大学 · 医学
佐々木淳一教授の研究室では、ウイルスの翻訳機構やタンパク質合成の分子機構に焦点を当てた研究を行っています。特に、翻訳開始にアミノ酸メチオニンを必要としない新しい翻訳機構を有する昆虫ウイルスの内部リボソーム認識部位（IRES）の解明が中心です。また、ペプチドグリカンの構造解析を通じて、細菌の細胞壁成分の立体化学的特徴についても独自の分析手法を用いて研究を展開しています。
Figures are computed from collected data and may differ slightly.
AUG-unrelated translation initiation was found in an insect picorna-like virus, Plautia stali intestine virus (PSIV). The positive-strand RNA genome of the virus contains two nonoverlapping open reading frames (ORFs). The capsid protein gene is located in the 3'-proximal ORF and lacks an AUG initiation codon. We examined the translation mechanism and the initiation codon of the capsid protein gene by using various dicistronic and monocistronic RNAs in vitro. The capsid protein gene was translate
Protein synthesis is believed to be initiated with the amino acid methionine because the AUG translation initiation codon of mRNAs is recognized by the anticodon of initiator methionine transfer RNA. A group of positive-stranded RNA viruses of insects, however, lacks an AUG translation initiation codon for their capsid protein gene, which is located at the downstream part of the genome. The capsid protein of one of these viruses, Plautia stali intestine virus, is synthesized by internal ribosome
An HPLC procedure which separates D- and L-amino acid isomers was applied to an analysis of peptidoglycan of 2,4-diaminobutyric acid (DAB)-containing actinomycetes. The cell wall peptidoglycans of species of the genera Agromyces, Clavibacter and Rathayibacter contain DAB and have been differentiated principally by their menaquinone profile. These peptidoglycans are known to be identical in structure, all being of the B2 gamma type, possessing both D- and L-DAB. The type strains of all the subspe
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