Yonsei University · 医学
Professor Junsik Park's research lab focuses on translational and clinical oncology, particularly in gynecologic malignancies such as epithelial ovarian cancer (EOC). The lab investigates immune microenvironment dynamics, especially the role of CD8+ T cells and response to immune checkpoint inhibitors like anti-PD-1, with a strong emphasis on how *BRCA1/2* mutation status influences treatment outcomes. They also explore the efficacy and safety of novel therapeutic strategies, including bevacizumab-containing neoadjuvant chemotherapy, aiming to improve progression-free and overall survival in advanced ovarian cancer. Their work bridges pathology, immunotherapy, and clinical trial design, with a focus on identifying biomarkers and personalized treatment approaches.
Figures are computed from collected data and may differ slightly.
South Korea’s social distancing policies on public transportation only involve mandatory wearing of masks and prohibition of food intake, similar to policies on other indoor spaces. This is not because public transportation is safe from coronavirus disease 2019 (COVID-19), but because no suitable policies based on accurate data have been implemented. To relieve fears regarding contracting COVID-19 infection through public transportation, the government should provide accurate information and tak
ClinicalTrials.gov Identifier: NCT04734665.
NCT03899610.
See "Early experiences with PD-1 inhibitor treatment of platinum resistant epithelial ovarian cancer" in volume 30, e56.
Bevacizumab-containing NAC might be safe and provide longer PFS than chemotherapy alone in patients with advanced ovarian cancer. However, further study is necessary to investigate the impact of bevacizumab-containing NAC on OS.
In gynecology, endosalpingiosis is a benign condition in which the fallopian tube-like epithelium is found outside the fallopian tube. The thirty-four point five percent of endosalpingiosis cases have concurrent endometriosis and 40% of the endosalpingiosis group are in postmenopausal states. In contrast with endometriosis, there are no significant links between infertility, chronic pelvic pain and endosalpingiosis. The symptoms of endosalpingiosis are not yet settled. Endosalpingiosis is almost
Our results highlight unique immune features of CD8<sup>+</sup> TILs in EOC and a differential response to anti-PD-1 treatment, contingent on <i>BRCA1/2</i> mutation status. These findings suggest that immune checkpoint blockade may be a promising frontline therapeutic option for selected <i>BRCA1/2</i>wt EOC patients.
Allogenic peripheral blood stem cell transplantation (Allo-PBSCT) is being used to treat hematological malignancies with increasing frequency. Graft-versus-host disease (GvHD) is a complex complication of PBSCT. A 43-year-old woman came to the gynecology clinic for amenorrhea. She had been diagnosed with acute myeloid leukemia 2 years earlier and treated with induction and consolidation chemotherapy. After developing complete remission, she underwent Allo-PBSCT. When she started chemotherapy, he
Abstract Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults and is manifested with poor prognosis. GBM has long been recognized as an immunosuppressive neoplasm characterized by activation of various immune escape mechanisms. Recently, immune checkpoint inhibitors have shown clinically relevant improvements with high response rates and durable tumor remissions in several cancer types, and anti-PD-1, PD-L1 and CTLA-4 blockade are currently tested in clinical trials for
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