東京工業大学 · 物理学・天文学
K. Nakajima教授の研究室では、原子間力顕微鏡を用いたナノスケールの機械的性質評価に注力しており、特にソフトマテリアルや高分子膜の粘弾性を高精度で測定する技術開発を進めています。HertzやJKRモデルを応用した力-変位曲線解析により、ナノスケールでの弾性率や接着エネルギーのマッピングを実現しており、がんマーカーの同定など医療応用への展開も視野に入れた多角的アプローチをとっています。
Figures are computed from collected data and may differ slightly.
We review nano-palpation atomic force microscopy, which offers quantitative mechanical property mapping especially for soft materials. The method measures force-deformation curves on the surfaces of soft materials. The emphasis is placed on how both Hertzian and Derjaguin-Muller-Toporov contact mechanics fail to reproduce the experimental curves and, alternatively, how the Johnson-Kendall-Roberts model does. We also describe the force-volume technique for obtaining a two-dimensional map of mecha
The goal of this study was to investigate Cystatin SN, a cysteine protease inhibitor, as a novel tumor marker for colorectal cancer (CRC). Gene expression profiles of mRNA from normal tissues and cancer cell lines were performed. Twenty-eight monoclonal antibodies for Cystatin SN were generated and serum Cystatin SN was quantified using ELISA in sera from 159 patients with CRC and 40 healthy controls. Cystatin SN was highly expressed in colon cancer cells. Employing a receiver-operating characte
We measured force–distance curves of polystyrene (PS)/poly (vinyl methyl ether) (PVME) blend thin films using atomic force microscopy (AFM) in order to pursue the possible usage of AFM as a tool for detecting viscoelastic properties of polymeric materials from a nanoscopic point of view. In quasi-static measurements of force–distance curves for a sample whose PS content equals 100%, both adhesive force and capillary force were measured separately. A phenomenon possibly assigned to pulling off of
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