東京大学 · 生化学・遺伝学・分子生物学
Shin-ya教授の研究室は、微生物から産生される天然物質、特にポリケチド合成酵素（PKS）を用いた新規医薬候補化合物の同定とバイオサイケルの解明を主な研究テーマとしています。特に、ストレプトマイセス属の海洋由来菌が産生するテロメラーゼ阻害剤「テロメスタチン」の発見や、巨大なモジュラーPKSの遺伝子クラスターのホストヘラスな発現・機能解析により、天然物の生合成機構の理解を深めています。また、遺伝子クラスターの進化と機能の関係を系統解析で解明することで、新規化合物の合成ルートの再プログラミングにも貢献しています。
Figures are computed from collected data and may differ slightly.
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTelomestatin, a Novel Telomerase Inhibitor from Streptomyces anulatusKazuo Shin-ya, Konstanty Wierzba, Ken-ichi Matsuo, Toshio Ohtani, Yuji Yamada, Kazuo Furihata, Yoichi Hayakawa, and Haruo SetoView Author Information Institute of Molecular and Cellular Biosciences The University of Tokyo Bunkyo-ku, Tokyo 113-0032, Japan Graduate School of Agricultural and Life Sciences The University of Tokyo Bunkyo-ku, Tokyo 113-8657, Japan Cite this: J. Am. C
Polyketides form many clinically valuable compounds. However, manipulation of their biosynthesis remains highly challenging. An understanding of gene cluster evolution provides a rationale for reprogramming of the biosynthetic machinery. Herein, we report characterization of giant modular polyketide synthases (PKSs) responsible for the production of aminopolyol polyketides. Heterologous expression of over 150 kbp polyketide gene clusters successfully afforded their products, whose stereochemistr
Terrestrial actinobacteria have served as a primary source of bioactive compounds; however, a rapid decrease in the discovery of new compounds strongly necessitates new investigational approaches. One approach is the screening of actinobacteria from marine habitats, especially the members of the genus Streptomyces. Presence of this genus in a marine sponge, Haliclona sp., was investigated using culture-dependent and -independent techniques. 16S rRNA gene clone library analysis showed the presenc
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